The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Natural killer cells in antiviral immunity

NK Björkström, B Strunz, HG Ljunggren - Nature Reviews Immunology, 2022 - nature.com
Natural killer (NK) cells play an important role in innate immune responses to viral infections.
Here, we review recent insights into the role of NK cells in viral infections, with particular …

Natural killer cell immunotypes related to COVID-19 disease severity

C Maucourant, I Filipovic, A Ponzetta, S Aleman… - Science …, 2020 - science.org
Understanding innate immune responses in coronavirus disease 2019 (COVID-19) is
important to decipher mechanisms of host responses and interpret disease pathogenesis …

Tissue-resident immune cells in humans

JI Gray, DL Farber - Annual review of immunology, 2022 - annualreviews.org
Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

[HTML][HTML] Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection

JK Files, S Boppana, MD Perez… - The Journal of …, 2021 - Am Soc Clin Investig
Ongoing observational clinical research has prioritized understanding the human immune
response to SARS-CoV-2 during the coronavirus disease 2019 (COVID-19) pandemic …

Human NK cells: From development to effector functions

AS Perera Molligoda Arachchige - Innate immunity, 2021 - journals.sagepub.com
NK cells are the major lymphocyte subset of the innate immune system that mediates
antiviral and anti-tumor responses. It is well established that they develop mechanisms to …

Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in …

Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood

D Brownlie, M Scharenberg, JE Mold… - Proceedings of the …, 2021 - National Acad Sciences
Human adaptive-like “memory” CD56dimCD16+ natural killer (NK) cells in peripheral blood
from cytomegalovirus-seropositive individuals have been extensively investigated in recent …

Dynamic natural killer cell and T cell responses to influenza infection

K Frank, S Paust - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Influenza viruses have perplexed scientists for over a hundred years. Yearly vaccines limit
their spread, but they do not prevent all infections. Therapeutic treatments for those …

Natural killer cells and type 1 innate lymphoid cells in cancer

N Lopes, E Vivier, E Narni-Mancinelli - Seminars in Immunology, 2023 - Elsevier
Innate lymphoid cells (ILCs) are a group of innate lymphocytes that do not express RAG-
dependent rearranged antigen-specific cell surface receptors. ILCs are classified into five …