Puberty is a major maturational event; its mechanisms and timing are driven by genetic
determinants, but also controlled by endogenous and environmental cues. Substantial …

DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …

Sex is a modulator of health that has been historically overlooked in biomedical research.
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …

Cancer risk is modulated by hereditary and somatic mutations, exposures, age, sex, and
gender. The mechanisms by which sex and gender work alone and in combination with …

Exposure to adverse childhood experiences (ACEs) increases risk for mental and physical
health problems. Intergenerationally, mothers' ACEs predict children's health problems …

The prevalence and severity of many diseases differs by sex, potentially due to sex-specific
patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have …

Puberty is an important developmental period marked by hormonal, metabolic and immune
changes. Puberty also marks a shift in sex differences in susceptibility to asthma. Yet, little is …

Puberty is a critical process characterized by several physical and psychological changes
that culminate in the achievement of sexual maturation and fertility. The onset of puberty …

Background Genetic and environmental factors are implicated in many developmental
processes. Recent evidence, however, has suggested that epigenetic changes may also …

There is growing evidence that the prevalence of high blood pressure is increasing, and it
may have serious consequences. However, research on the prevalence and influencing …