Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in
hematologic malignancies, but its application to solid tumors has proven challenging. This …

Fibroblasts and macrophages are present in all tissues, and mounting evidence supports
that these cells engage in direct communication to influence the overall tissue …

The accumulation of senescent cells in the tumor microenvironment can drive tumorigenesis
in a paracrine manner through the senescence-associated secretory phenotype (SASP) …

Single-cell RNA sequencing (scRNA-seq) is a powerful tool for defining cellular diversity in
tumors, but its application toward dissecting mechanisms underlying immune-modulating …

Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …

Novel experimental approaches such as fate-mapping and single-cell analysis have brought
fresh insight into monocyte development and function over the past decade and helped …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is
upregulated on activated T cells for the induction of immune tolerance,. Tumour cells …

Abstract Purpose of Review Chronic wounds are a tremendous burden on the healthcare
system and lead to significant patient morbidity and mortality. Normal cutaneous wound …

The tumor-permissive and immunosuppressive characteristics of tumor-associated
macrophages (TAM) have fueled interest in therapeutically targeting these cells. In this …