Spatial transcriptomics in health and disease
S Jain, MT Eadon - Nature Reviews Nephrology, 2024 - nature.com
The ability to localize hundreds of macromolecules to discrete locations, structures and cell
types in a tissue is a powerful approach to understand the cellular and spatial organization …
types in a tissue is a powerful approach to understand the cellular and spatial organization …
[HTML][HTML] New tools to study renal fibrogenesis
X Liao, E Scheidereit, C Kuppe - Current Opinion in Nephrology …, 2024 - journals.lww.com
As further single-cell and spatial multiomic approaches are being developed, opportunities
to apply these methods to human kidney tissues expand similarly. Careful design and …
to apply these methods to human kidney tissues expand similarly. Careful design and …
Multi-omics data integration shines a light on the renal medulla
JB Hodgin, C Smith, M Kretzler - Kidney International, 2024 - Elsevier
The renal medulla maintains salt and water balance and is prone to dysregulation because
of high oxygen demand. Challenges in obtaining high-quality tissue have limited …
of high oxygen demand. Challenges in obtaining high-quality tissue have limited …
Nicotinamide riboside activates renal metabolism and protects the kidney in a model of Alport syndrome
Chronic kidney disease (CKD) is associated with renal metabolic disturbances, including
impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small …
impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small …
miRNA and mRNA Signatures in Human Acute Kidney Injury Tissue
D Janosevic, T De Luca, RM Ferreira, DL Gisch, T Hato… - bioRxiv, 2023 - biorxiv.org
Acute kidney injury (AKI) is an important contributor to the development of chronic kidney
disease (CKD). There is a need to understand molecular mediators that drive either recovery …
disease (CKD). There is a need to understand molecular mediators that drive either recovery …
Multiomic analysis of human kidney disease identifies a tractable inflammatory, pro-fibrotic tubular cell phenotype
B Conway, M Reck, D Baird, C Sutherland, R Bell… - 2024 - researchsquare.com
Maladaptive proximal tubular cells have been implicated in failure of repair following renal
injury in rodent models, however whether this translates to human kidney disease is …
injury in rodent models, however whether this translates to human kidney disease is …