To PEGylate or not to PEGylate: Immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives

D Shi, D Beasock, A Fessler, J Szebeni… - Advanced drug delivery …, 2022 - Elsevier
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional
formulations utilize PEG as either an active ingredient or an excipient. PEG found its use in …

[HTML][HTML] Safe nanoparticles: are we there yet?

W Najahi-Missaoui, RD Arnold… - International journal of …, 2020 - mdpi.com
The field of nanotechnology has grown over the last two decades and made the transition
from the benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles …

The dose threshold for nanoparticle tumour delivery

B Ouyang, W Poon, YN Zhang, ZP Lin, BR Kingston… - Nature materials, 2020 - nature.com
Nanoparticle delivery to solid tumours over the past ten years has stagnated at a median of
0.7% of the injected dose. Varying nanoparticle designs and strategies have yielded only …

Poly (ethylene glycol) in drug delivery: pros and cons as well as potential alternatives

K Knop, R Hoogenboom, D Fischer… - Angewandte chemie …, 2010 - Wiley Online Library
Abstract Poly (ethylene glycol)(PEG) is the most used polymer and also the gold standard for
stealth polymers in the emerging field of polymer‐based drug delivery. The properties that …

Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs

Y Lu, K Park - International journal of pharmaceutics, 2013 - Elsevier
Poorly soluble drugs often encounter low bioavailability and erratic absorption patterns in
the clinical setting. Due to the rising number of compounds having solubility issues, finding …

Recent advances in stealth coating of nanoparticle drug delivery systems

Z Amoozgar, Y Yeo - Wiley Interdisciplinary Reviews …, 2012 - Wiley Online Library
Modifying surfaces of nanoparticles (NPs) with polyethylene glycol (PEG), the so‐called
PEGylation, is the most commonly used method for reducing premature clearance of NPs …

Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties

SM Moghimi, J Szebeni - Progress in lipid research, 2003 - Elsevier
This article critically examines and evaluates the likely mechanisms that contribute to
prolonged circulation times of sterically protected nanoparticles and liposomes. It is …

Questioning the use of PEGylation for drug delivery

JJF Verhoef, TJ Anchordoquy - Drug delivery and translational research, 2013 - Springer
Polyethylene glycol (PEG) is widely utilized in drug delivery and nanotechnology due to its
reported “stealth” properties and biocompatibility. It is generally thought that PEGylation …

Stealth properties to improve therapeutic efficacy of drug nanocarriers

S Salmaso, P Caliceti - Journal of drug delivery, 2013 - Wiley Online Library
Over the last few decades, nanocarriers for drug delivery have emerged as powerful tools
with unquestionable potential to improve the therapeutic efficacy of anticancer drugs. Many …

Toxicological status of nanoparticles: what we know and what we don't know

WN Missaoui, RD Arnold, BS Cummings - Chemico-biological interactions, 2018 - Elsevier
The field of nanotechnology has grown exponentially during the last few decades, due in
part to the use of nanoparticles in many manufacturing processes, as well as their potential …