In less than a decade after discovery, RNA interference-mediated gene silencing is already
being tested as potential therapy in clinical trials for a number of diseases. Lentiviral vectors …

Studying the importance of genetic factors in a desired cell type or tissue necessitates the
use of precise genetic tools. With the introduction of bacteriophage Cre recombinase/loxP …

The use of RNA interference (RNAi) to inhibit gene expression is potentially applicable in
the treatment of viral infections such as hepatitis B virus (HBV) persistence. Although …

Conditional gene targeting using Cre recombinase has offered a powerful tool to modify
gene function precisely in defined cells/tissues and at specific times. However, in …

A decade after its discovery, RNA interference has proven to be an instant success both in
fundamental research and clinical applications. Lentiviral delivery of shRNAs is one of the …

Social and economic impacts of neurodegenerative diseases (NDs) become more
prominent in our constantly aging population. Currently, due to the lack of knowledge about …

Background RNA interference (RNAi) is a conserved gene silencing mechanism mediated
by small inhibitory microRNAs (miRNAs). Promoter-driven miRNA expression vectors have …

Conditional gene targeting using Cre recombinase has offered a powerful tool to modify 29
gene function precisely in defined cells/tissues and at specific times. However, in …

The use of transgenic animals in pulmonary research has greatly evolved in the past decade
as refinements in genetic techniques have enabled enhanced ability to manipulate gene …

Die Funktion eines Genes zu erforschen, indem man es ausschaltet, und damit seiner Rolle
im komplexen Zusammenspiel der einzelnen Prozesse des menschlichen Körpers …