Pathogen recognition by the innate immune system

H Kumar, T Kawai, S Akira - International reviews of immunology, 2011 - Taylor & Francis
Microbial infection initiates complex interactions between the pathogen and the host.
Pathogens express several signature molecules, known as pathogen-associated molecular …

MAMP (microbe-associated molecular pattern) triggered immunity in plants

MA Newman, T Sundelin, JT Nielsen… - Frontiers in plant …, 2013 - frontiersin.org
Plants are sessile organisms that are under constant attack from microbes. They rely on both
preformed defenses, and their innate immune system to ward of the microbial pathogens …

Gut microbiota-derived components and metabolites in the progression of non-alcoholic fatty liver disease (NAFLD)

Y Ji, Y Yin, Z Li, W Zhang - Nutrients, 2019 - mdpi.com
Human gut microbiota has been increasingly recognized as a pivotal determinant of non-
alcoholic fatty liver disease (NAFLD). Apart from the changes in the composition of gut …

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

L Franchi, T Eigenbrod, R Muñoz-Planillo… - Nature …, 2009 - nature.com
The inflammasome is a multiprotein complex that mediates the activation of caspase-1,
which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

DR Rose, H Yang, G Serena, C Sturgeon, B Ma… - Brain, behavior, and …, 2018 - Elsevier
Objectives Many studies have reported the increased presence of gastrointestinal (GI)
symptoms in children with autism spectrum disorders (ASD). Altered microbiome profiles …

The inflammasomes: guardians of the body

F Martinon, A Mayor, J Tschopp - Annual review of immunology, 2009 - annualreviews.org
The innate immune system relies on its capacity to rapidly detect invading pathogenic
microbes as foreign and to eliminate them. The discovery of Toll-like receptors (TLRs) …

Function of Nod‐like receptors in microbial recognition and host defense

L Franchi, N Warner, K Viani… - Immunological reviews, 2009 - Wiley Online Library
Nucleotide oligomerization domain (NOD)‐like receptors (NLRs) are a specialized group of
intracellular proteins that play a critical role in the regulation of the host innate immune …

Peptidoglycan muropeptides: release, perception, and functions as signaling molecules

O Irazoki, SB Hernandez, F Cava - Frontiers in microbiology, 2019 - frontiersin.org
Peptidoglycan (PG) is an essential molecule for the survival of bacteria, and thus, its
biosynthesis and remodeling have always been in the spotlight when it comes to the …

NOD-like receptors: role in innate immunity and inflammatory disease

G Chen, MH Shaw, YG Kim… - Annual Review of …, 2009 - annualreviews.org
The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that
represent a key component of the host innate immune system. Since the discovery of the first …

Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology

RS Mahla, MC Reddy, DVR Prasad… - Frontiers in …, 2013 - frontiersin.org
Innate sensors play a critical role in the early innate immune responses to invading
pathogens through sensing of diverse biochemical signatures also known as pathogen …