Cellular senescence and senolytics: the path to the clinic

S Chaib, T Tchkonia, JL Kirkland - Nature medicine, 2022 - nature.com
Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Cellular senescence: the good, the bad and the unknown

W Huang, LTJ Hickson, A Eirin, JL Kirkland… - Nature Reviews …, 2022 - nature.com
Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

[HTML][HTML] Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

Z Cui, X Zhao, FK Amevor, X Du, Y Wang, D Li… - Frontiers in …, 2022 - frontiersin.org
Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …

Senescent cells: a therapeutic target in cardiovascular diseases

M Suda, KH Paul, T Minamino, JD Miller, A Lerman… - Cells, 2023 - mdpi.com
Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

[HTML][HTML] The effect of eight weeks resistance and endurance training on some angiogenesis factors of hippocampus tissue in male wistar rats

M Sadegh Ghomi, M Kashef… - Journal of Sport and …, 2021 - joeppa.sbu.ac.ir
Purpose: One of the cause of adaptations due to exercise training is increased capillary
density or angiogenesis. increased blood flow to hippocampus tissue causes improvement …

مقایسة اثر تمرین تناوبی شدید و مقاومتی فزاینده بر بیان ژن ATF3 عضلة قلبی موش‌های صحرایی دیابتی نر

سفال منش, شهاب الدین, خالدی, ندا, رجبی… - نشریه فیزیولوژی ورزش و …, 2021‎ - joeppa.sbu.ac.ir
هدف: از سازوکارهای مؤثر در انجام بهتر عملکرد عضلانی در ورزشکاران، القای ظرفیت
پیش‌فعال‌سازی (PAP) در روش گرم کردن است. ازاین‌رو، پژوهش حاضر به‌منظور بررسی تأثیر گرم …

Therapeutic opportunities for senolysis in cardiovascular disease

M Sweeney, SA Cook, J Gil - The FEBS journal, 2023 - Wiley Online Library
Cellular senescence within the cardiovascular system has, until recently, been understudied
and unappreciated as a factor in the development of age‐related cardiovascular diseases …

Quercetin: a bioactive compound imparting cardiovascular and neuroprotective benefits: scope for exploring fresh produce, their wastes, and by-products

IUH Bhat, R Bhat - Biology, 2021 - mdpi.com
Simple Summary The present review summarizes the generated hypothesis and critical role
of quercetin in cardiovascular and neuroprotective diseases reported over the last decade …

Targeting cardiovascular diseases by flavonols: An update

A Kozłowska, D Szostak-Węgierek - Nutrients, 2022 - mdpi.com
Flavonols are one of the most plentiful flavonoid subclasses found in natural products and
are extensively used as dietary supplements. Numerous in vitro and in vivo studies have …

[HTML][HTML] Regulation of main ncRNAs by polyphenols: A novel anticancer therapeutic approach

L Zhang, Q Kang, M Kang, S Jiang, F Yang, J Gong… - Phytomedicine, 2023 - Elsevier
Background Plant polyphenols have shown promising applications in oncotherapy.
Increasing evidence reveals that polyphenols possess the antitumor potential for multiple …