Relevance of viroporin ion channel activity on viral replication and pathogenesis

JL Nieto-Torres, C Verdiá-Báguena… - Viruses, 2015 - mdpi.com
Modification of host-cell ionic content is a significant issue for viruses, as several viral
proteins displaying ion channel activity, named viroporins, have been identified. Viroporins …

Chloroviruses: not your everyday plant virus

JL Van Etten, DD Dunigan - Trends in plant science, 2012 - cell.com
Viruses infecting higher plants are among the smallest viruses known and typically have four
to ten protein-encoding genes. By contrast, many viruses that infect algae (classified in the …

Screening blockers against a potassium channel with a droplet interface bilayer array

R Syeda, MA Holden, WL Hwang… - Journal of the American …, 2008 - ACS Publications
Droplet interface bilayers (DIBs) form between two lipid monolayer-encased aqueous
droplets submerged in oil. Both major structural classes of membrane proteins, α-helix …

Designing a polycationic probe for simultaneous enrichment and detection of microRNAs in a nanopore

K Tian, Z He, Y Wang, SJ Chen, LQ Gu - ACS nano, 2013 - ACS Publications
The nanopore sensor can detect cancer-derived nucleic acid biomarkers such as
microRNAs (miRNAs), providing a noninvasive tool potentially useful in medical diagnostics …

Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers

LM Winterstein, K Kukovetz, O Rauh… - Journal of General …, 2018 - rupress.org
Recent studies have shown that membrane proteins can be efficiently synthesized in vitro
before spontaneously inserting into soluble nanoscale lipid bilayers called nanodiscs (NDs) …

Single locked nucleic acid-enhanced nanopore genetic discrimination of pathogenic serotypes and cancer driver mutations

K Tian, X Chen, B Luan, P Singh, Z Yang, KS Gates… - ACS …, 2018 - ACS Publications
Accurate and rapid detection of single-nucleotide polymorphism (SNP) in pathogenic
mutants is crucial for many fields such as food safety regulation and disease diagnostics …

[HTML][HTML] Minimal art: or why small viral K+ channels are good tools for understanding basic structure and function relations

G Thiel, D Baumeister, I Schroeder, SM Kast… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Some algal viruses contain genes that encode proteins with the hallmarks of K+ channels.
One feature of these proteins is that they are less than 100 amino acids in size, which make …

Memantine hydrochloride: a drug to be repurposed against Chikungunya virus?

AKS Pereira, IA Santos, WW da Silva… - Pharmacological …, 2021 - Springer
Background Chikungunya fever is an endemic disease caused by the Chikungunya virus
(CHIKV) to which there is no vaccine or effective antiviral drug treatment so far. Our study …

Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block

FC Chatelain, S Gazzarrini, Y Fujiwara, C Arrigoni… - PLoS …, 2009 - journals.plos.org
Background Understanding the interactions between ion channels and blockers remains an
important goal that has implications for delineating the basic mechanisms of ion channel …

[HTML][HTML] Chlorella viruses evoke a rapid release of K+ from host cells during the early phase of infection

M Neupärtl, C Meyer, I Woll, F Frohns, M Kang… - Virology, 2008 - Elsevier
Infection of Chlorella NC64A cells by PBCV-1 produces a rapid depolarization of the host
probably by incorporation of a viral-encoded K+ channel (Kcv) into the host membrane. To …