Estimating the complier average causal effect in a meta-analysis of randomized clinical trials with binary outcomes accounting for noncompliance: A generalized linear …
Noncompliance, a common problem in randomized clinical trials (RCTs), can bias
estimation of the effect of treatment receipt using a standard intention-to-treat analysis. The …
estimation of the effect of treatment receipt using a standard intention-to-treat analysis. The …
A survey of methodologies on causal inference methods in meta-analyses of randomized controlled trials
Background Meta-analyses of randomized controlled trials (RCTs) have been considered as
the highest level of evidence in the pyramid of the evidence-based medicine. However, the …
the highest level of evidence in the pyramid of the evidence-based medicine. However, the …
Causally interpretable meta‐analysis: Clearly defined causal effects and two case studies
Meta‐analysis is commonly used to combine results from multiple clinical trials, but
traditional meta‐analysis methods do not refer explicitly to a population of individuals to …
traditional meta‐analysis methods do not refer explicitly to a population of individuals to …
Generalizing the intention-to-treat effect of an active control from historical placebo-controlled trials: A case study of the efficacy of daily oral TDF/FTC in the HPTN 084 …
In many clinical settings, an active-controlled trial design (eg, a non-inferiority or superiority
design) is often used to compare an experimental medicine to an active control (eg, an FDA …
design) is often used to compare an experimental medicine to an active control (eg, an FDA …
Variability in Causal Effects and Noncompliance in a Multisite Trial: A Bivariate Hierarchical Generalized Random Coefficients Model for a Binary Outcome
X Sun, Y Shin, JE Lafata… - Statistics in …, 2024 - Wiley Online Library
Within each of 170 physicians, patients were randomized to access e‐assist, an online
program that aimed to increase colorectal cancer screening (CRCS), or control. Compliance …
program that aimed to increase colorectal cancer screening (CRCS), or control. Compliance …
Sensitivity of estimands in clinical trials with imperfect compliance
H Chen, DF Heitjan - The international journal of biostatistics, 2024 - degruyter.com
In clinical trials that are subject to noncompliance, the commonly used intention-to-treat
estimand is valid as a causal effect of treatment assignment but is sensitive to the level of …
estimand is valid as a causal effect of treatment assignment but is sensitive to the level of …
Estimating the Complier Average Causal Effect with Non-Ignorable Missing Outcomes Using Likelihood Analysis
J Du, G Wen, X Liang - Mathematics, 2024 - mdpi.com
Missing data problems arise in randomized trials, which complicates the inference of causal
effects if the missing mechanism is non-ignorable. We tackle the challenge of identifying and …
effects if the missing mechanism is non-ignorable. We tackle the challenge of identifying and …
Transportability of Principal Causal Effects
Recent research in causal inference has made important progress in addressing challenges
to the external validity of trial findings. Such methods weight trial participant data to more …
to the external validity of trial findings. Such methods weight trial participant data to more …
A Bayesian hierarchical CACE model accounting for incomplete noncompliance with application to a meta-analysis of epidural analgesia on cesarean section
Noncompliance with assigned treatments is a common challenge in analyzing and
interpreting randomized clinical trials (RCTs). One way to handle noncompliance is to …
interpreting randomized clinical trials (RCTs). One way to handle noncompliance is to …
Generalizing the intention-to-treat effect of an active control against placebo from historical placebo-controlled trials to an active-controlled trial: A case study of the …
Q He, F Gao, O Dukes, S Delany-Moretlwe… - arXiv preprint arXiv …, 2023 - arxiv.org
In many clinical settings, an active-controlled trial design (eg, a non-inferiority or superiority
design) is often used to compare an experimental medicine to an active control (eg, an FDA …
design) is often used to compare an experimental medicine to an active control (eg, an FDA …