The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Type 2 diabetes continues to negatively impact the health of millions. The inability to
respond to insulin to clear blood glucose (insulin resistance) is a key pathogenic driver of …

Dicarbonyl stress occurs when dicarbonyl metabolites (ie, methylglyoxal, glyoxal and 3-
deoxyglucosone) accumulate as a consequence of their increased production and/or …

A comprehensive comparison of metabolomic, lipidomic, and proteomic profiles was
conducted between the breast and leg muscles of Shitou goose (STE) and Wuzhong goose …

Abstract Di-(2-ethylhexyl) phthalate (DEHP) in the environment and food chain may impact
cerebrum development and neurobehavioral in humans and wildlife. However, it is unclear …

Insulin resistance (IR), designated as the blunted response of insulin target tissues to
physiological level of insulin, plays crucial roles in the development and progression of …

Aims Nighttime aircraft noise exposure has been associated with increased risk of
hypertension and myocardial infarction, mechanistically linked to sleep disturbance, stress …

Since the discovery of the nuclear factor erythroid-derived 2-like 2 (Nrf2) transcription factor
thirty years ago, it has been shown that it regulates more than 250 genes involved in a …

The development of obesity-associated complications is related to various pathogenic
events including chronic inflammation, oxidative stress and generation of advanced …