The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Huntington's disease (HD) is a hereditary progressive neurodegenerative disorder caused
by a CAG repeat expansion in the gene coding for the protein huntingtin, resulting in a …

The understanding of the functional and structural changes occurring in the cerebral cortex
and basal ganglia in Huntington's disease (HD) has benefited considerably from the …

Brain cholesterol is produced mainly by astrocytes and is important for neuronal function. Its
biosynthesis is severely reduced in mouse models of Huntington's disease. One possible …

Huntington's disease (HD) is one of main neurodegenerative diseases, characterized by
striatal atrophy, involuntary movements, and motor incoordination. Ginsenoside Rg1 (Rg1) …

We used behavioral testing and morphological methods to detail the progression of basal
ganglia neuron type‐specific pathology and the deficits stemming from them in male …

Huntington's Disease (HD) is an autosomal dominant, progressive neurodegenerative
disorder caused by deleterious expansion of CAG repeats in the Huntingtin gene and …

The debilitating psychomotor symptoms of Huntington9s disease (HD) are linked partly to
degeneration of the basal ganglia indirect pathway. At early symptomatic stages, before …

Dendritic regression of striatal spiny projection neurons (SPNs) is a pathological hallmark of
Parkinson's disease (PD). Here we investigate how chronic dopamine denervation and …