Brain development, sensory information processing, and learning and memory processes
depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of …

Highlights•Synaptic strength depends on nanoscale alignment of release and clustered
receptors.•Diverse mechanisms of altered alignment can contribute to synaptic …

RIMs and RIM-binding proteins (RBPs) are evolutionary conserved multidomain proteins of
presynaptic active zones that are known to recruit Ca 2+ channels; in addition, RIMs perform …

Neuronal communication across synapses relies on neurotransmitter release from
presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic …

Ultrafast neurotransmitter release requires tight colocalization of voltage-gated Ca 2+
channels with primed, release-ready synaptic vesicles at the presynaptic active zone. RIM …

At the presynaptic active zone, action-potential-triggered neurotransmitter release requires
that fusion-competent synaptic vesicles are placed next to Ca 2+ channels. The active zone …

The tight spatial coupling of synaptic vesicles and voltage-gated Ca2+ channels (CaVs)
ensures efficient action potential-triggered neurotransmitter release from presynaptic active …

Neurons communicate through Ca2+-dependent neurotransmitter release at presynaptic
active zones (AZs). Neurotransmitter release properties play a key role in defining …

The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …

Ribbon synapses of inner hair cells (IHCs) mediate high rates of synchronous exocytosis to
indefatigably track the stimulating sound with sub-millisecond precision. The sophisticated …