Adolescence is a developmental period when physical and cognitive abilities are optimized,
when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal …

The Neurobiology of Adolescent Drinking in Adulthood (NADIA) Consortium has focused on
the impact of adolescent binge drinking on brain development, particularly on effects that …

Background The high prevalence and burden to society of drug abuse and addiction is
undisputed. However, its conceptualisation as a brain disease is controversial, and …

The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …

Alcoholism is a complex brain disease characterized by three distinct stages of the addiction
cycle that manifest as neuroadaptive changes in the brain. One such stage of the addiction …

Epidemiology is the branch of science that investigates the causes and distribution of
disease in populations in order to provide preventative measures and promote human …

Family, twin and adoption studies demonstrate clearly that alcohol dependence and alcohol
use disorders are phenotypically complex and heritable. The heritability of alcohol use …

Stress-related disorders, such as anxiety, early life stress, and posttraumatic stress disorder
appear to be important factors in promoting alcoholism, as alcohol consumption can …

Alcohol use disorder (AUD) is a complex brain disorder with an array of persistent
behavioral and neurochemical manifestations. Both genetic and environmental factors are …

Binge drinking during adolescence is a risk factor for neuropsychiatric disorders that can
develop later in life. Histone acetylation is an important epigenetic mechanism that …