Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Brain function requires a constant supply of glucose. However, the brain has no known
energy stores, except for glycogen granules in astrocytes. In the present study, we report that …

The human diet and dietary patterns are closely linked to the health status. High-calorie
Western-style diets have increasingly come under scrutiny as their caloric load and …

Reactive oxygen species (ROS) are highly reactive molecules that can oxidize proteins,
lipids, and DNA. Under physiological conditions, ROS are mainly generated in the …

Autophagy mediates cellular quality control mechanisms and energy homeostasis through
lysosomal degradation. Autophagy is typically viewed as an adaptive process that allows …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Background: Caloric restriction mimetics (CRMs) mimic the favourable effects of caloric
restriction (CR) and have been shown to have therapeutic effects in neuroinflammatory …