Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

Ion channels and transporters move ions across membrane barriers and are essential for a
host of cell functions in many organs. They conduct K+, Na+ and Cl−, which are essential for …

In this review article, we discuss the different gene products and translational variants of
ORAI proteins and their contribution to the makeup of different native calcium-conducting …

Background Store-operated Ca 2+ entry (SOCE) through Ca 2+ release–activated Ca 2+
channels is an essential signaling pathway in many cell types. Ca 2+ release–activated Ca …

Ameloblasts are specialized epithelial cells in the jaw that have an indispensable role in
tooth enamel formation—amelogenesis. Amelogenesis depends on multiple ameloblast …

Fluoride ions are highly reactive, and their incorporation in forming dental enamel at low
concentrations promotes mineralization. In contrast, excessive fluoride intake causes dental …

Store-operated Ca2+ entry (SOCE) channels are highly selective Ca2+ channels activated
by the endoplasmic reticulum (ER) sensors STIM1 and STIM2. Their direct interaction with …

Abstract Background Calcium (Ca2+) signaling regulates various vital cellular functions,
including integrin activation and cell migration. Store-operated calcium entry (SOCE) via …

Fluoride is commonly consider as a “double-edged sword” because low consumption of
fluoride can effectively prevent dental caries, but excessive consumption of fluoride can …

Enamel is the most calcified tissue in vertebrates. It differs from bone in a number of
characteristics including its origin from ectodermal epithelium, lack of remodeling capacity …