Specialized membrane domains are an important feature of almost all cells. In particular,
they are essential to tissues that have a highly organized cell cortex, such as the intestinal …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

A better understanding of the extent of convergent selection among crops could greatly
improve breeding programs. We found that the quantitative trait locus KRN2 in maize and its …

Detection of viruses by innate immune sensors induces protective antiviral immunity. The
viral DNA sensor cyclic GMP-AMP synthase (cGAS) is necessary for detection of HIV by …

The Drosophila genome contains> 13000 protein-coding genes, the majority of which
remain poorly investigated. Important reasons include the lack of antibodies or reporter …

Systematic mapping of protein–protein interactions, or 'interactome'mapping, was initiated in
model organisms, starting with defined biological processes, and then expanding to the …

Protein-protein interaction maps provide a valuable framework for a better understanding of
the functional organization of the proteome. To detect interacting pairs of human proteins …

Background One challenge facing biologists is to tease out useful information from massive
data sets for further analysis. A pathway-based analysis may shed light by projecting …

A key property of complex biological systems is the presence of interaction networks formed
by its different components, primarily proteins. These are crucial for all levels of cellular …

In plants, nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins can
form receptor networks to confer hypersensitive cell death and innate immunity. One class of …