Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary
tumor in the central nervous system. One of the most widely used chemotherapeutic drugs …

Glioblastoma (GBM) is among the most treatment-resistant solid tumors and often recurrs
after resection. One of the mechanisms through which GBM escapes various treatment …

Gliomas are the most common and challenging malignancies of the central nervous system
(CNS), due to their infiltrative nature, tendency to recurrence, and poor response to …

Glioblastoma (GBM) is the most malignant brain tumor and accounts for most adult brain
tumors. Current available treatment options for GBM are multimodal, which include surgical …

Glioma is the most aggressive brain tumor of the central nervous system. The ability of
glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained …

Accumulating evidence has demonstrated that human cancers arise from various tissues of
origin that initiate from cancer stem cells (CSCs) or cancer-initiating cells. The extrinsic and …

Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal
primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate …

Certain gliomas often harbor a mutation in the activity center of IDH1 (R132H), which leads
to the production of the oncometabolite 2-R-2-hydroxyglutarate (2-HG). In six model …

Malignant cells routinely violate cellular checkpoints that should initiate cell death in normal
cells by triggering pro‐apoptotic members of the BCL‐2 family of proteins. To escape such …