Background: SCN1A is one of the most common epilepsy genes. About 80% of SCN1A
gene mutations cause Dravet syndrome (DS), which is a severe and catastrophic epileptic …

While traditional forensic genetics has been oriented towards using human DNA in criminal
investigation and civil court cases, it currently presents a much wider application range …

Every year in the United States, approximately 3500 infants die of sleep-related infant
deaths, including sudden infant death syndrome (SIDS)(International Statistical …

Importance Understanding the causes of infant mortality shapes public health, surveillance,
and research investments. However, the association of single-locus (mendelian) genetic …

Sudden cardiac death (SCD) accounts for 10–20% of total mortality, ie, one in five
individuals will eventually die suddenly. Given the substantial genetic component of SCD in …

Background In the majority of cases, the cause of stillbirth remains unknown despite detailed
clinical and laboratory evaluation. Approximately 10 to 20% of stillbirths are attributed to …

Background: Sudden infant death syndrome (SIDS) is a leading cause of postneonatal
mortality. Genetic heart diseases (GHDs) underlie some cases of SIDS. Objectives: This …

Background Neuropathic pain is common in peripheral neuropathy. Recent genetic studies
have linked pathogenic voltage-gated sodium channel (VGSC) variants to human pain …

The term sudden infant death syndrome (SIDS) was first proposed in 1969 in order to focus
attention on a subgroup of infants with similar clinical features whose deaths occurred …

Purpose This study aimed to evaluate genetic contributions to sudden unexpected death in
pediatrics (SUDP). Methods We phenotyped and performed exome sequencing for 352 …