What is life without oxygen is a rhetorical question. On the other hand, unraveling the
intricacies and understanding the various mechanisms underpinning the biological …

The reaction of flavoenzymes with oxygen remains a fascinating area of research because
of its relevance for reactive oxygen species (ROS) generation. Several exciting recent …

Among the molecular mechanisms of adaptation in biology, enzyme functional
diversification is indispensable. By allowing organisms to expand their catalytic repertoires …

Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …

Flavin-containing monooxygenases (FMOs) are ubiquitous in all domains of life and
metabolize a myriad of xenobiotics, including toxins, pesticides and drugs. However, despite …

Baeyer-Villiger monooxygenases catalyze the oxidation of carbonylic substrates to ester or
lactone products using NADPH as electron donor and molecular oxygen as oxidative …

The Baeyer–Villiger monooxygenases (BVMOs) are a family of bacterial flavoproteins that
catalyze the synthetically useful Baeyer–Villiger oxidation reaction. This involves the …

Flavin-containing mono-oxygenases are known as potent drug-metabolizing enzymes,
providing complementary functions to the well-investigated cytochrome P450 mono …

Determination of the mechanism of dioxygen activation by flavoenzymes remains one of the
most challenging problems in flavoenzymology for which the underlying theoretical basis is …

SidA from the human pathogen Aspergillus fumigatus catalyzes the generation of N 5-
hydroxyornithine in the biosynthesis of siderophores, a reaction essential for virulence. The …