Cell adhesion by integrins

M Bachmann, S Kukkurainen… - Physiological …, 2019 - journals.physiology.org
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

J Huang, X Li, X Shi, M Zhu, J Wang, S Huang… - Journal of hematology & …, 2019 - Springer
Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Talins and kindlins: partners in integrin-mediated adhesion

DA Calderwood, ID Campbell… - Nature reviews Molecular …, 2013 - nature.com
Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

The final steps of integrin activation: the end game

SJ Shattil, C Kim, MH Ginsberg - Nature reviews Molecular cell biology, 2010 - nature.com
Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Integrin signalling at a glance

DS Harburger, DA Calderwood - Journal of cell science, 2009 - journals.biologists.com
It has been brought to our attention that there is an error in the poster published in
association with this article. Non-phosphorylated ICAP1 is shown to bind to the cytoplasmic …

Genetic and cell biological analysis of integrin outside-in signaling

KR Legate, SA Wickström, R Fässler - Genes & development, 2009 - genesdev.cshlp.org
Integrins are cell surface transmembrane receptors that recognize and bind to extracellular
matrix proteins and counter receptors. Binding of activated integrins to their ligands induces …

The tail of integrins, talin, and kindlins

M Moser, KR Legate, R Zent, R Fässler - Science, 2009 - science.org
Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …

Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

S Li, C Sampson, C Liu, H Piao, HX Liu - Cell Communication and …, 2023 - Springer
Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

Integrin inactivators: balancing cellular functions in vitro and in vivo

D Bouvard, J Pouwels, N De Franceschi… - Nature reviews Molecular …, 2013 - nature.com
Integrins mediate cell–matrix and cell–cell interactions and integrate extracellular cues to
the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is …

The structure of an integrin/talin complex reveals the basis of inside‐out signal transduction

NJ Anthis, KL Wegener, F Ye, C Kim, BT Goult… - The EMBO …, 2009 - embopress.org
Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane
proteins that uniquely mediate inside‐out signal transduction, whereby adhesion to the …