Emerging Carbapenem-Resistant Enterobacteriaceae Infection, Its Epidemiology and Novel Treatment Options: A Review
M Tilahun, Y Kassa, A Gedefie… - Infection and drug …, 2021 - Taylor & Francis
Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …
public health problem due to the inadequate treatment options and the historically lagged …
The revival of aztreonam in combination with avibactam against metallo-β-lactamase-producing Gram-negatives: a systematic review of in vitro studies and clinical …
Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and
Pseudomonas are increasingly reported worldwide and are usually associated with high …
Pseudomonas are increasingly reported worldwide and are usually associated with high …
Cefiderocol for the treatment of infections due to metallo-B-lactamase–producing pathogens in the CREDIBLE-CR and APEKS-NP phase 3 randomized studies
In the CREDIBLE-CR and APEKS-NP studies, cefiderocol treatment was effective against
gram-negative bacteria producing metallo-B-lactamases; rates of clinical cure …
gram-negative bacteria producing metallo-B-lactamases; rates of clinical cure …
Early appropriate diagnostics and treatment of MDR Gram-negative infections
The term difficult-to-treat resistance has been recently coined to identify Gram-negative
bacteria exhibiting resistance to all fluoroquinolones and all β-lactam categories, including …
bacteria exhibiting resistance to all fluoroquinolones and all β-lactam categories, including …
In vitro activity of cefiderocol against MBL-producing Gram-negative bacteria collected in North America and Europe in five consecutive annual multinational SIDERO …
M Takemura, MG Wise, MA Hackel… - Journal of …, 2023 - academic.oup.com
Objectives To evaluate the in vitro antibacterial activity of cefiderocol, a siderophore
cephalosporin against MBL-producing clinical isolates. Methods MBL-producing strains …
cephalosporin against MBL-producing clinical isolates. Methods MBL-producing strains …
Kinetics, thermodynamics, and structural effects of quinoline-2-carboxylates, zinc-binding inhibitors of New Delhi metallo-β-lactamase-1 Re-sensitizing multidrug …
Y Jia, B Schroeder, Y Pfeifer, C Fröhlich… - Journal of Medicinal …, 2023 - ACS Publications
Carbapenem resistance mediated by metallo-β-lactamases (MBL) such as New Delhi
metallo-β-lactamase-1 (NDM-1) has become a major factor threatening the efficacy of …
metallo-β-lactamase-1 (NDM-1) has become a major factor threatening the efficacy of …
Aztreonam–avibactam versus meropenem for the treatment of serious infections caused by Gram-negative bacteria (REVISIT): a descriptive, multinational, open-label …
Background There is a need for additional therapeutic options for serious infections caused
by Gram-negative pathogens. In the phase 3, descriptive REVISIT study, we investigated the …
by Gram-negative pathogens. In the phase 3, descriptive REVISIT study, we investigated the …
Microbiological, clinical, and PK/PD features of the new anti-Gram-negative antibiotics: β-lactam/β-lactamase inhibitors in combination and cefiderocol—an all …
L Principe, T Lupia, L Andriani, F Campanile… - Pharmaceuticals, 2022 - mdpi.com
Bacterial resistance mechanisms are continuously and rapidly evolving. This is particularly
true for Gram-negative bacteria. Over the last decade, the strategy to develop new β …
true for Gram-negative bacteria. Over the last decade, the strategy to develop new β …
Multicenter evaluation of an MIC-based aztreonam and ceftazidime-avibactam broth disk elution test
Due to limited therapeutic options, there is a clinical need to assess the in vitro activity of the
combination of aztreonam (ATM) and ceftazidime-avibactam (CZA) to guide the therapeutic …
combination of aztreonam (ATM) and ceftazidime-avibactam (CZA) to guide the therapeutic …
Carbapenem-resistant Klebsiella pneumoniae: the role of plasmids in emergence, dissemination, and evolution of a major clinical challenge
V Di Pilato, S Pollini, V Miriagou… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction Klebsiella pneumoniae is a major agent of healthcare-associated infections and
a cause of some community-acquired infections, including severe bacteremic infections …
a cause of some community-acquired infections, including severe bacteremic infections …