Diverse heterochromatin states restricting cell identity and reprogramming
Heterochromatin is defined as a chromosomal domain harboring repressive H3K9me2/3 or
H3K27me3 histone modifications and relevant factors that physically compact the chromatin …
H3K27me3 histone modifications and relevant factors that physically compact the chromatin …
Role of the epigenome in heart failure
Gene expression is needed for the maintenance of heart function under normal conditions
and in response to stress. Each cell type of the heart has a specific program controlling …
and in response to stress. Each cell type of the heart has a specific program controlling …
An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype
Background Association of chromatin with lamin proteins at the nuclear periphery has
emerged as a potential mechanism to coordinate cell type-specific gene expression and …
emerged as a potential mechanism to coordinate cell type-specific gene expression and …
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes
PP Shah, W Lv, JH Rhoades, A Poleshko, D Abbey… - Cell Stem Cell, 2021 - cell.com
Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …
Lamina associated domains and gene regulation in development and cancer
The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear
membrane, thereby providing a platform for chromatin binding and supporting genome …
membrane, thereby providing a platform for chromatin binding and supporting genome …
Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors
The nuclear architecture of rod photoreceptor cells in nocturnal mammals is unlike that of
other animal cells. Murine rod cells have an “inverted” chromatin organization with …
other animal cells. Murine rod cells have an “inverted” chromatin organization with …
[HTML][HTML] Attach and stretch: Emerging roles for genome–lamina contacts in shaping the 3D genome
PMJ Rullens, J Kind - Current Opinion in Cell Biology, 2021 - Elsevier
A large proportion of the metazoan genome is spatially segregated at the nuclear periphery
through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that …
through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that …
Growth factor–induced activation of MSK2 leads to phosphorylation of H3K9me2S10 and corresponding changes in gene expression
KG Wong, YCF Cheng, VH Wu, AA Kiseleva, J Li… - Science …, 2024 - science.org
Extracellular signals are transmitted through kinase cascades to modulate gene expression,
but it remains unclear how epigenetic changes regulate this response. Here, we provide …
but it remains unclear how epigenetic changes regulate this response. Here, we provide …
Histone methyltransferase activity programs nuclear peripheral genome positioning
Spatial organization of the genome in the nucleus plays a critical role in development and
regulation of transcription. A genomic region that resides at the nuclear periphery is part of …
regulation of transcription. A genomic region that resides at the nuclear periphery is part of …
Three-dimensional chromatin organization in cardiac development and disease
A Bertero, M Rosa-Garrido - Journal of molecular and cellular cardiology, 2021 - Elsevier
Recent technological advancements in the field of chromatin biology have rewritten the
textbook on nuclear organization. We now appreciate that the folding of chromatin in the …
textbook on nuclear organization. We now appreciate that the folding of chromatin in the …