Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

▪ Abstract Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially
discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide …

Brain-derived neurotrophic factor (BDNF) regulates neuronal development and function.
However, it has been difficult to discern its role in the adult brain in influencing complex …

Hyperpolarization‐activated cation currents (Ih) contribute to various physiological
properties and functions in the brain, including neuronal pacemaker activity, setting of …

An ion channel's function depends largely on its location and density on neurons. Here we
used high-resolution immunolocalization to determine the subcellular distribution of the …

Seed-dispersal mutualisms have a fundamental role in regenerating natural communities,.
Interest in the importance of seed dispersal to plant communities has been heightened by …

Members of the HCN channel family generate hyperpolarization-activated cation currents
(Ih) that are directly regulated by cAMP and contribute to pacemaker activity in heart and …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …

Neuropathic pain is a common and often incapacitating clinical problem for which little
useful therapy is presently available. Painful peripheral neuropathies can have many …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal
excitability and their dysfunction has been linked to epileptogenesis but few individuals with …