Acute kidney injury and distant organ dysfunction–network system analysis

R Matsuura, K Doi, H Rabb - Kidney international, 2023 - Elsevier
Acute kidney injury (AKI) occurs in about half of critically ill patients and is associated with
high in-hospital mortality, increased long-term mortality postdischarge, and subsequent …

Short-chain fatty acid receptors and blood pressure regulation: council on hypertension mid-career award for research excellence 2021

J Xu, BN Moore, JL Pluznick - Hypertension, 2022 - Am Heart Assoc
The gut microbiome influences host physiology and pathophysiology through several
pathways, one of which is microbial production of chemical metabolites which interact with …

[HTML][HTML] Occurrence, risk assessment, and in vitro and in vivo toxicity of antibiotics in surface water in China

C Zhang, Y Chen, S Chen, X Guan, Y Zhong… - … and Environmental Safety, 2023 - Elsevier
Antibiotics have been widely detected in the water environment and thus pose a potential
threat to human health. Although antibiotics have health-promoting properties, whether and …

Guidelines for microbiome studies in renal physiology

RR Muralitharan, M Snelson, G Meric… - American Journal …, 2023 - journals.physiology.org
Gut microbiome research has increased dramatically in the last decade, including in renal
health and disease. The field is moving from experiments showing mere association to …

Intestinal microbiota dysbiosis in acute kidney injury: novel insights into mechanisms and promising therapeutic strategies

J Lei, Y Xie, J Sheng, J Song - Renal failure, 2022 - Taylor & Francis
In recent years, the clinical impact of intestinal microbiota–kidney interaction has been
emerging. Experimental evidence highlighted a bidirectional evolutionary correlation …

Targeting the gut microbiota in kidney disease: The future in renal nutrition and metabolism

K Lambert, E Rinninella, A Biruete, K Sumida… - Journal of Renal …, 2023 - Elsevier
There is increasing interest in the therapeutic potential of manipulating the gut microbiome
of patients with chronic kidney disease (CKD). This is because there is a substantial …

Lymphocytes and innate immune cells in acute kidney injury and repair

K Lee, HR Jang, H Rabb - Nature Reviews Nephrology, 2024 - nature.com
Acute kidney injury (AKI) is a common and serious disease entity that affects native kidneys
and allografts but for which no specific treatments exist. Complex intrarenal inflammatory …

Vancomycin induced ferroptosis in renal injury through the inactivation of recombinant glutathione peroxidase 4 and the accumulation of peroxides

X Yin, Q Yang, H Li, Y Kang, Z Li - Drug Design, Development and …, 2023 - Taylor & Francis
Background Vancomycin (VCM) has long been used clinically to fight against Gram-positive
bacterial infections. In recent decades, an increased number of kidney injury cases caused …

[HTML][HTML] Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and …

J Lee, J Lee, K Kim, J Lee, Y Jung, JS Hyeon, A Seo… - Kidney international, 2024 - Elsevier
Intestinal microbiota and their metabolites affect systemic inflammation and kidney disease
outcomes. Here, we investigated the key metabolites associated with the acute kidney injury …

[HTML][HTML] Role of T cells in ischemic acute kidney injury and repair

K Lee, HR Jang - The Korean Journal of Internal Medicine, 2022 - ncbi.nlm.nih.gov
Ischemic acute kidney injury (AKI) is a common medical problem with significant mortality
and morbidity, affecting a large number of patients globally. Ischemic AKI is associated with …