Connecting epicardial adipose tissue and heart failure with preserved ejection fraction: mechanisms, management and modern perspectives

G van Woerden, DJ van Veldhuisen… - European Journal of …, 2022 - Wiley Online Library
Obesity is very common in patients with heart failure with preserved ejection fraction
(HFpEF) and it has been suggested that obesity plays an important role in the …

The role of epicardial adipose tissue dysfunction in cardiovascular diseases: An overview of pathophysiology, evaluation, and management

C Li, X Liu, BK Adhikari, L Chen, W Liu… - Frontiers in …, 2023 - frontiersin.org
In recent decades, the epicardial adipose tissue (EAT) has been at the forefront of scientific
research because of its diverse role in the pathogenesis of cardiovascular diseases (CVDs) …

Haemodynamic and metabolic phenotyping of patients with aortic stenosis and preserved ejection fraction: a specific phenotype of heart failure with preserved …

N De Biase, M Mazzola, L Del Punta… - European Journal of …, 2023 - Wiley Online Library
Aims Degenerative aortic valve stenosis with preserved ejection fraction (ASpEF) and heart
failure with preserved ejection fraction (HFpEF) display intriguing similarities. This study …

Epicardial adipose tissue density is a better predictor of cardiometabolic risk in HFpEF patients: a prospective cohort study

J Liu, Q Yu, Z Li, Y Zhou, Z Liu, L You, L Tao… - Cardiovascular …, 2023 - Springer
Background Epicardial adipose tissue (EAT) accumulation is associated with multiple
cardiometabolic risk factors and prognosis of heart failure with preserved ejection fraction …

Obesity, heart failure with preserved ejection fraction, and the role of glucagon‐like peptide‐1 receptor agonists

G Cimino, M Vaduganathan, CM Lombardi… - ESC heart …, 2024 - Wiley Online Library
Heart failure with preserved ejection fraction (HFpEF) has a high prevalence, affecting more
than 50% of patients with heart failure. HFpEF is associated with multiple comorbidities, and …

Obesity, preserved ejection fraction heart failure, and left ventricular remodeling

J Stencel, HR Alai, A Dhore-Patil… - Journal of Clinical …, 2023 - mdpi.com
Owing to the overwhelming obesity epidemic, preserved ejection fraction heart failure
commonly ensues in patients with severe obesity and the obese phenotype of preserved …

The different pathways of epicardial adipose tissue across the heart failure phenotypes: from pathophysiology to therapeutic target

VA Rossi, M Gruebler, L Monzo, A Galluzzo… - International Journal of …, 2023 - mdpi.com
Epicardial adipose tissue (EAT) is an endocrine and paracrine organ constituted by a layer
of adipose tissue directly located between the myocardium and visceral pericardium. Under …

Sodium-glucose cotransporter 2 inhibitors induce anti-inflammatory and anti-ferroptotic shift in epicardial adipose tissue of subjects with severe heart failure

BJ Kasperova, M Mraz, P Svoboda, D Hlavacek… - Cardiovascular …, 2024 - Springer
Background Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are glucose-lowering
agents used for the treatment of type 2 diabetes mellitus, which also improve heart failure …

Heart failure with preserved ejection fraction epidemiology, pathophysiology, diagnosis and treatment strategies

A Abdin, M Böhm, B Shahim, P Karlström… - International Journal of …, 2024 - Elsevier
The prevalence of HF with preserved ejection raction (HFpEF, with EF≥ 50%) is increasing
across all populations with high rates of hospitalization and mortality, reaching up to 80 …

Heart Failure Treatment in 2023: Is There a Place for Lipid Lowering Therapy?

H Poloczková, J Krejčí - Current Atherosclerosis Reports, 2023 - Springer
Abstract Purpose of Review An evidence for lipid lowering therapy in heart failure is briefly
summarized in this review. Recent Findings Heart failure therapy is based on recent …