During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

The two universally required components of the intracellular membrane fusion machinery,
SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular …

In poikilotherms, temperature changes challenge the integration of physiological function.
Within the complex nervous systems of the behaviorally sophisticated coleoid cephalopods …

Synaptotagmin, complexin, and neuronal SNARE (soluble N-ethylmaleimide sensitive factor
attachment protein receptor) proteins mediate evoked synchronous neurotransmitter …

Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …

Upon entering a presynaptic terminal, an action potential opens Ca2+ channels, and
transiently increases the local Ca2+ concentration at the presynaptic active zone. Ca2+ then …

Mice carrying a mutation in the synaptotagmin I gene were generated by homologous
recombination. Mutant mice are phenotypically normal as heterozygotes, but die within 48 …

The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer
predisposition syndromes. PTEN is a phosphatase that can act on both polypeptide and …

Membrane fusion can occur between cells, between different intracellular compartments,
between intracellular compartments and the plasma membrane and between lipid-bound …

In all synapses, Ca2+ triggers neurotransmitter release to initiate signal transmission. Ca2+
presumably acts by activating synaptic Ca2+ sensors, but the nature of these sensors …