Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates

I Alshareedah, WM Borcherds, SR Cohen, A Singh… - Nature Physics, 2024 - nature.com
Biomolecular condensates are viscoelastic materials. Here we investigate the determinants
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …

Influence of nonstoichiometry on the viscoelastic properties of a polyelectrolyte complex

Y Chen, M Yang, SA Shaheen, JB Schlenoff - Macromolecules, 2021 - ACS Publications
Depending on conditions such as the mixing ratio, speed and order of addition, and ionic
strength, when solutions of oppositely charged polyelectrolytes are mixed, the stoichiometry …

Extreme dependence of dynamics on concentration in highly crowded polyelectrolyte solutions

H Landfield, N Kalamaris, M Wang - Science Advances, 2024 - science.org
Charge-carrying species, such as polyelectrolytes, are vital to natural and synthetic
processes that rely on their dynamic behavior. Through single-particle tracking techniques …

Valence-induced jumps in coacervate properties

M Yang, ZA Digby, Y Chen, JB Schlenoff - Science Advances, 2022 - science.org
Spontaneous phase separation, or coacervation, of oppositely charged macromolecules is a
powerful and ubiquitous mechanism for the assembly of natural and synthetic materials. Two …

Understanding How Metal–Ligand Coordination Enables Solvent Free Ionic Conductivity in PDMS

X Zhang, J Dai, M Tepermeister, Y Deng, J Yeo… - …, 2023 - ACS Publications
Ionically conductive polymers are commonly made of monomers containing high polarity
moieties to promote high ion dissociation, like poly (ethylene oxide)(PEO), polyvinylidene …

Self-exchange of polyelectrolyte in multilayers: Diffusion as a function of salt concentration and temperature

RL Abbett, Y Chen, JB Schlenoff - Macromolecules, 2021 - ACS Publications
Polymer chain diffusion within a hydrated polyelectrolyte complex, PEC, has been measured
using an ultrathin film format prepared by the layer-by-layer method. Isotopically labeled self …

Solvent-Responsive Glass Transition Behavior of Polyelectrolyte Complexes

H Li, D Tolmachev, P Batys, M Sammalkorpi… - …, 2024 - ACS Publications
Polyelectrolyte complexes (PECs) have attracted considerable attention owing to their
unique physicochemical properties and potential applications as smart materials. Herein …

Diffusive Trends in Concentrated Oppositely-Charged Polyelectrolyte Solutions and Onset of Glassy Dynamics

H Landfield, M Wang - ACS Macro Letters, 2024 - ACS Publications
We utilize single particle tracking studies to investigate the diffusion of polylysine through
concentrated matrices of cationic polylysine and anionic polyglutamic acid with no added …

Unifying the temperature dependent dynamics of glass formers

JB Schlenoff, K Akkaoui - The Journal of Chemical Physics, 2024 - pubs.aip.org
Strong changes in bulk properties, such as modulus and viscosity, are observed near the
glass transition temperature, T g, of amorphous materials. For more than a century, intense …

Sequence-specific interactions determine viscoelastic moduli and aging dynamics of protein condensates

I Alshareedah, W Borcherds, S Cohen, M Farag… - 2023 - researchsquare.com
Biomolecular condensates that form via phase separation coupled to percolation are
complex viscoelastic materials whose properties are thought to influence cellular functions …