The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress
Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …
The tuberculous granuloma and preexisting immunity
Pulmonary granulomas are widely considered the epicenters of the immune response to
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …
[HTML][HTML] The role of IL-10 in immune regulation during M. tuberculosis infection
PS Redford, PJ Murray, A O'garra - Mucosal immunology, 2011 - Elsevier
During gaseous exchange the lungs are exposed to a vast variety of pathogens, allergens,
and innocuous particles. A feature of the lung immune response to lung-tropic aerosol …
and innocuous particles. A feature of the lung immune response to lung-tropic aerosol …
The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
R Mirzaei, F Mahdavi, F Badrzadeh… - International …, 2021 - Elsevier
The novel coronavirus disease 2019 (COVID-19) pandemic has imposed significant public
health problems for the human populations worldwide after the 1918 influenza A virus …
health problems for the human populations worldwide after the 1918 influenza A virus …
siRNA therapeutics against respiratory viral infections—What have we learned for potential COVID‐19 therapies?
Acute viral respiratory tract infections (AVRIs) are a major burden on human health and
global economy and amongst the top five causes of death worldwide resulting in an …
global economy and amongst the top five causes of death worldwide resulting in an …
Tuberculosis drug discovery in the post‐post‐genomic era
B Lechartier, J Rybniker, A Zumla… - EMBO molecular …, 2014 - embopress.org
The expectation that genomics would result in new therapeutic interventions for infectious
diseases remains unfulfilled. In the post‐genomic era, the decade immediately following the …
diseases remains unfulfilled. In the post‐genomic era, the decade immediately following the …
[HTML][HTML] TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma
CD4 T cell effector function is required for optimal containment of Mycobacterium
tuberculosis (Mtb) infection. IFNɣ produced by CD4 T cells is a key cytokine that contributes …
tuberculosis (Mtb) infection. IFNɣ produced by CD4 T cells is a key cytokine that contributes …
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
RE Lee, JG Hurdle, J Liu, DF Bruhn, T Matt… - Nature medicine, 2014 - nature.com
Although the classical antibiotic spectinomycin is a potent bacterial protein synthesis
inhibitor, poor antimycobacterial activity limits its clinical application for treating tuberculosis …
inhibitor, poor antimycobacterial activity limits its clinical application for treating tuberculosis …
Host-directed therapy targeting the Mycobacterium tuberculosis granuloma: a review
Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major
cause of morbidity and mortality worldwide. Slow progress has been made in lessening the …
cause of morbidity and mortality worldwide. Slow progress has been made in lessening the …
[HTML][HTML] TB and COVID-19: An Exploration of the Characteristics and Resulting Complications of Co-infection
E Luke, K Swafford, G Shirazi… - Frontiers in bioscience …, 2022 - ncbi.nlm.nih.gov
Abstract Tuberculosis (TB) and Coronavirus Disease-19 (COVID-19) infection are two
respiratory diseases that are of particular concern epidemiologically. Tuberculosis is one of …
respiratory diseases that are of particular concern epidemiologically. Tuberculosis is one of …