Proposal to consider chemical/physical microenvironment as a new therapeutic off-target approach

A Giuliani, S Fais - Pharmaceutics, 2022 - mdpi.com
The molecular revolution could lead drug discovery from chance observation to the rational
design of new classes of drugs that could simultaneously be more effective and less toxic …

Sulfasalazine for the treatment of preeclampsia in a nitric oxide synthase antagonist mouse model

NK Binder, N de Alwis, S Beard, E Kadife, A Harper… - Placenta, 2023 - Elsevier
Introduction Development of a therapeutic that targets the pathophysiological elements of
preeclampsia would be a major advance for obstetrics, with potential to save the lives of …

Effect of Curcumin on Nitric Oxide and Endothelin-1 Levels in L-NAME-Induced Preeclamptic Wistar Rat

B Rahardjo, RF Dewi, IWA Wiyasa… - Majalah Kedokteran …, 2024 - journal.fk.unpad.ac.id
Preeclampsia is a pregnancy disorder marked by the onset of hypertension after the 20th
week, posing risks such as cardiovascular disease. Curcumin, a commonly consumed …