Bipolar disorder (BD) poses a significant public health concern, with roughly one‐quarter of
sufferers attempting suicide. BD is characterized by manic and depressive mood cycles, the …

Prokaryotes have evolved a multitude of defense systems to protect against phage
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …

Adenosine-5'-triphosphate (ATP) is generally regarded as a substrate for energy currency
and protein modification. Recent findings uncovered the allosteric function of ATP in cellular …

Review covering up to 2021 Cyclitols derived from carbohydrates are naturally stable
hydrophilic substances under ordinary physiological conditions, increasing the water …

As the prototypical member of the PTP family, protein tyrosine phosphatase 1B (PTP1B) is
an attractive target for therapeutic interventions in type 2 diabetes. The extremely conserved …

Inositol depletion is a hypothesized mechanism of action of mood stabilization drugs used in
the treatment of bipolar disorder. It was previously reported that the mood stabilizer …

Glycogen synthase kinase 3β (GSK3β) is a ubiquitous serine/threonine kinase that plays a
pivotal role in many biological processes. GSK3β catalyzes the transfer of γ‐phosphate of …

Abstract Development of multi-target drugs is becoming increasingly attractive in the
repertoire of protein kinase inhibitors discovery. In this study, we carried out molecular …

Molecular recognition is rarely a two-body protein-ligand problem, as it often involves the
dynamic interplay of multiple molecules that together control the binding process. Myo …

Allostery is the most efficient means of regulating protein functions, ranging from the control
of metabolic mechanisms to signal transduction pathways. Although allosteric regulation has …