The Pig‐a (phosphatidylinositol glycan, Class A) gene codes for a catalytic subunit of the N‐
acetylglucosamine transferase complex involved in an early step of glycosylphosphatidyl …

Abstract The International Life Sciences Institute (ILSI) Health and Environmental Sciences
Institute (HESI) Project Committee on the Relevance and Follow‐up of Positive Results in In …

The in vivo Pig-a assay uses flow cytometry to measure phenotypic variants for antibody
binding to cell surface glycosylphosphatidylinositol (GPI)-anchored proteins. There is good …

Silver nanoparticles (AgNPs) are among the most commercially used nanomaterials and
their toxicity and genotoxicity are controversial. Although many in vitro studies have been …

The ability to effectively monitor gene mutation and micronucleated reticulocyte (MN-RET)
frequency in short-term and repeated dosing schedules was investigated using the recently …

In vivo mutation assays based on the Pig-a null phenotype, that is, the absence of cell
surface glycosylphosphatidylinositol (GPI) anchored proteins such as CD59, have been …

The working group reached complete or majority agreement on many issues. Results from
TGR and in vivo comet assays for 91 chemicals showed they have similar ability to detect in …

Two endpoints of genetic toxicity, mutation at the X-linked Pig-a gene and chromosomal
damage in the form of micronucleated reticulocytes (MN-RETs), were evaluated in blood …

A collaborative international trial was conducted to evaluate the reproducibility and
transferability of an in vivo mutation assay based on the enumeration of CD59‐negative rat …

In this study we compared the response of the Pig‐a gene mutation assay to that of the lacZ
transgenic rodent mutation assay, and demonstrated that multiple endpoints can be …