Patients with castration-resistant prostate cancer inevitably acquire resistance to
antiandrogen therapies in part because of androgen receptor (AR) mutations or splice …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

The incidence rate of prostate cancer (PCa) has risen by 3% per year from 2014 through
2019 in the United States. An estimated 34,700 people will die from PCa in 2023 …

Mutations of the androgen receptor (AR) associated with prostate cancer and androgen
insensitivity syndrome may profoundly influence its structure, protein interaction network …

Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative and neuromuscular
genetic disease caused by the expansion of a polyglutamine-encoding CAG tract in the …

The topology of biological polymers such as proteins and nucleic acids is an important
aspect of their 3D structure. Recently, two applications of topology to molecular chains have …

The androgen receptor (AR), a member of the nuclear steroid hormone receptor family of
transcription factors, plays a crucial role not only in the development of the male phenotype …

Understanding the binding behavior and conformational dynamics of intrinsically disordered
proteins (IDPs) is crucial for unraveling their regulatory roles in biological processes …

Intrinsically disordered proteins (IDPs) lack a stable native conformation, making it
challenging to characterize their structure and dynamics. Key topological motifs with …

Building on the theory of circuit topology for intra-chain contacts in entangled proteins, we
introduce tiles as a way to rigorously model local entanglements which are held in place by …