Chemistry and structural biology of androgen receptor

W Gao, CE Bohl, JT Dalton - Chemical reviews, 2005 - ACS Publications
Androgen receptor (AR) is a member of the steroid and nuclear receptor superfamily, 1
which is composed of over 100 members and continues to grow. Among this large family of …

Therapeutic strategies to target the androgen receptor

W Xiang, S Wang - Journal of Medicinal Chemistry, 2022 - ACS Publications
The androgen receptor (AR) plays a key role in the maintenance of muscle and bone and
the support of male sexual-related functions, as well as in the progression of prostate …

European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters

Z Tousova, P Oswald, J Slobodnik, L Blaha… - Science of the Total …, 2017 - Elsevier
Growing concern about the adverse environmental and human health effects of a wide
range of micropollutants requires the development of novel tools and approaches to enable …

The truncated wigner method for bose-condensed gases: limits of validity and applications1

A Sinatra, C Lobo, Y Castin - … of Physics B: Atomic, Molecular and …, 2002 - iopscience.iop.org
We study the truncated Wigner method applied to a weakly interacting spinless Bose-
condensed gas which is perturbed away from thermal equilibrium by a time-dependent …

Selective androgen receptor modulators in preclinical and clinical development

R Narayanan, ML Mohler, CE Bohl… - Nuclear receptor …, 2008 - journals.sagepub.com
Androgen receptor (AR) plays a critical role in the function of several organs including
primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable …

Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling …

AM Alaa - European journal of medicinal chemistry, 2007 - Elsevier
Versatile method has been developed for synthesis of N-substituted imides. Thus, acid
anhydrides, imides and dicarboxylic acids were successfully subjected to dehydrative …

Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with …

J Ostrowski, JE Kuhns, JA Lupisella… - …, 2007 - academic.oup.com
A novel, highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR)
modulator (BMS-564929) has been identified, and this compound has been advanced to …

Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands

W Gao, J Kim, JT Dalton - Pharmaceutical research, 2006 - Springer
Testosterone and structurally related anabolic steroids have been used to treat
hypogonadism, muscle wasting, osteoporosis, male contraception, cancer cachexia …

In silico evidence of beauvericin antiviral activity against SARS-CoV-2

C Al Khoury, Z Bashir, S Tokajian, N Nemer… - Computers in Biology …, 2022 - Elsevier
Background Scientists are still battling severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the virus responsible for the coronavirus 2019 (COVID-19) pandemic so …

Targeting alternative sites on the androgen receptor to treat castration-resistant prostate cancer

N Lallous, K Dalal, A Cherkasov… - International journal of …, 2013 - mdpi.com
Recurrent, metastatic prostate cancer continues to be a leading cause of cancer-death in
men. The androgen receptor (AR) is a modular, ligand-inducible transcription factor that …