THC and CBD: villain versus hero? Insights into adolescent exposure
Cannabis is the most used drug of abuse worldwide. It is well established that the most
abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and …
abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and …
Epigenetic studies for evaluation of NPS toxicity: focus on synthetic cannabinoids and cathinones
L Mazdai, M Fabbri, M Tirri, G Corli, R Arfè, B Marchetti… - Biomedicines, 2022 - mdpi.com
In the recent decade, numerous new psychoactive substances (NPSs) have been added to
the illicit drug market. These are synthetized to mimic the effects of classic drugs of abuse …
the illicit drug market. These are synthetized to mimic the effects of classic drugs of abuse …
Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions
During adolescence, frequent and heavy cannabis use can lead to serious adverse health
effects and cannabis use disorder (CUD). Rodent models of adolescent exposure to the …
effects and cannabis use disorder (CUD). Rodent models of adolescent exposure to the …
Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice
Rationale The use of synthetic cannabinoid receptor agonists (SCRAs) is growing among
adolescents, posing major medical and psychiatric risks. JWH-018 represents the reference …
adolescents, posing major medical and psychiatric risks. JWH-018 represents the reference …
Adolescent exposure to the Spice/K2 cannabinoid JWH-018 impairs sensorimotor gating and alters cortical perineuronal nets in a sex-dependent manner
C Izquierdo-Luengo, M Ten-Blanco… - Translational …, 2023 - nature.com
The consumption of synthetic cannabinoids during adolescence is reported to be a risk
factor for the appearance of psychiatric disorders later in life. JWH-018 was identified as one …
factor for the appearance of psychiatric disorders later in life. JWH-018 was identified as one …
Deletion of Cryab increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 via upregulation of striatal NF-κB expression
LV Sayson, DM Ortiz, HJ Lee, M Kim… - Frontiers in …, 2023 - frontiersin.org
Synthetic cannabinoids have exhibited unpredictable abuse liabilities, especially self-
administration (SA) responses in normal rodent models, despite seemingly inducing …
administration (SA) responses in normal rodent models, despite seemingly inducing …
Cognitive dysfunction and impaired neuroplasticity following repeated exposure to the synthetic cannabinoid JWH‐018 in male mice
Abstract Background and Purpose Psychotic disorders have been reported in long‐term
users of synthetic cannabinoids. This study aims at investigating the long‐lasting effects of …
users of synthetic cannabinoids. This study aims at investigating the long‐lasting effects of …
Emission of 50-kHz ultrasonic vocalizations stimulated by antiparkinsonian dopaminomimetic drugs in hemiparkinsonian rats is associated with neuronal activation in …
Dopamine replacement therapy (DRT) of Parkinson's disease (PD) may trigger non-motor
complications, some of which affect hedonic homeostatic regulation. Management of …
complications, some of which affect hedonic homeostatic regulation. Management of …
[HTML][HTML] Evidence for enduring cardiac and multiorgan toxicity after repeated exposure to the synthetic cannabinoid JWH-018 in male rats
The use of synthetic cannabinoid receptor agonists (SCRAs) represents a public health
concern. Besides abuse liability and cognitive impairments, SCRAs consumption is …
concern. Besides abuse liability and cognitive impairments, SCRAs consumption is …
Frustrative nonreward and cannabinoid receptors: Chronic (but not acute) WIN 55,212-2 treatment increased resistance to change in two reward downshift tasks
SE Conrad, D Davis, N Vilcek, JB Thompson… - Pharmacology …, 2022 - Elsevier
Assessing the role of cannabinoid (CB) receptors in behavior is relevant given the trend
toward the legalization of medicinal and recreational marijuana. The present research aims …
toward the legalization of medicinal and recreational marijuana. The present research aims …