Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges

PC Vioglio, MR Chierotti, R Gobetto - Advanced Drug Delivery Reviews, 2017 - Elsevier
In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

Mechanochemistry: opportunities for new and cleaner synthesis

SL James, CJ Adams, C Bolm, D Braga… - Chemical Society …, 2012 - pubs.rsc.org
The aim of this critical review is to provide a broad but digestible overview of
mechanochemical synthesis, ie reactions conducted by grinding solid reactants together …

Calcination‐regulated Microstructures of Donor‐Acceptor Polymers towards Enhanced and Stable Photocatalytic H2O2 Production in Pure Water

C Yang, S Wan, B Zhu, J Yu… - Angewandte Chemie …, 2022 - Wiley Online Library
Regulating molecular structure of donor‐acceptor (D‐A) polymer is a promising strategy to
improve photoactivity. Herein, a porous nanorod‐like D‐A polymer is synthesized via a …

Mechanochemical preparation of co-crystals

D Braga, L Maini, F Grepioni - Chemical Society Reviews, 2013 - pubs.rsc.org
The preparation of co-crystals via mechanochemistry combines the quest for clean and
green processes with the investigation of multicomponent new materials, among the …

The salt− cocrystal continuum: the influence of crystal structure on ionization state

SL Childs, GP Stahly, A Park - Molecular pharmaceutics, 2007 - ACS Publications
Salts and cocrystals are multicomponent crystals that can be distinguished by the location of
the proton between an acid and a base. At the salt end of the spectrum proton transfer is …

Recent advances in understanding the mechanism of cocrystal formation via grinding

T Friscic, W Jones - Crystal Growth and Design, 2009 - ACS Publications
A brief and systematic overview of recent advances in understanding the mechanism of
mechanochemical cocrystallization at macroscopic (bulk phase transformations) and …

Solvent-assisted mechanochemistry

GA Bowmaker - Chemical Communications, 2013 - pubs.rsc.org
The literature on solvent-assisted mechanochemistry is reviewed with a view to linking
observations concerning the applicability of the technique to theories of its mechanism, and …

A decade update on solvent and catalyst-free neat organic reactions: a step forward towards sustainability

A Sarkar, S Santra, SK Kundu, A Hajra, GV Zyryanov… - Green …, 2016 - pubs.rsc.org
Particular success has been achieved in the synthesis of new products and in processes
since the twelve principles of “green chemistry” were formulated in the 1990s. These …

Solvent‐free and catalysts‐free chemistry: a benign pathway to sustainability

MB Gawande, VDB Bonifacio, R Luque… - …, 2014 - Wiley Online Library
In the past decade, alternative benign organic methodologies have become an imperative
part of organic syntheses and chemical reactions. The various new and innovative …

Eutectics as improved pharmaceutical materials: design, properties and characterization

S Cherukuvada, A Nangia - Chemical Communications, 2014 - pubs.rsc.org
Eutectics are a long known class of multi-component solids with important and useful
applications in daily life. In comparison to other multi-component crystalline solids, such as …