Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

Over the past 20 years, the zebrafish has emerged as a powerful model organism for
studying cardiac development. Its ability to survive without an active circulation and …

Recent studies indicate that mammals, including humans, maintain some capacity to renew
cardiomyocytes throughout postnatal life,. Yet, there is little or no significant cardiac muscle …

The AAA+ ATPases are enzymes containing a P-loop NTPase domain, and function as
molecular chaperones, ATPase subunits of proteases, helicases or nucleic-acid-stimulated …

Some organisms, such as adult zebrafish and newborn mice, have the capacity to
regenerate heart tissue following injury. Unraveling the mechanisms of heart regeneration is …

Background In humans, myocardial infarction is characterized by irreversible loss of heart
tissue, which becomes replaced with a fibrous scar. By contrast, teleost fish and urodele …

Polycystic kidney disease (PKD) is a common human genetic illness. It is characterized by
the formation of multiple kidney cysts that are thought to result from over-proliferation of …

Mammals respond to a myocardial infarction by irreversible scar formation. By contrast,
zebrafish are able to resolve the scar and to regenerate functional cardiac muscle. It is not …

Telomerase is a multisubunit ribonucleoprotein (RNP) complex that adds telomere repeats
to the ends of chromosomes. Three essential telomerase components have been identified …

Visualizing the cell cycle behavior of individual cells within living organisms can facilitate the
understanding of developmental processes such as pattern formation, morphogenesis, cell …