Preschool multiple-breath washout testing. An official American Thoracic Society technical statement
PD Robinson, P Latzin, KA Ramsey… - American journal of …, 2018 - atsjournals.org
Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial
tree, although the extent to which this occurs can vary among conditions. The multiple …
tree, although the extent to which this occurs can vary among conditions. The multiple …
Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis
KJ Bayfield, TA Douglas, T Rosenow, JC Davies… - Thorax, 2021 - thorax.bmj.com
Structural and functional defects within the lungs of children with cystic fibrosis (CF) are
detectable soon after birth and progress throughout preschool years often without overt …
detectable soon after birth and progress throughout preschool years often without overt …
Effects of lumacaftor–ivacaftor on lung clearance index, magnetic resonance imaging, and airway microbiome in Phe508del homozygous patients with cystic fibrosis
SY Graeber, S Boutin, MO Wielpütz… - Annals of the …, 2021 - atsjournals.org
Rationale: Previous studies showed that lumacaftor–ivacaftor therapy results in partial
rescue of CFTR (cystic fibrosis [CF] transmembrane conductance regulator) activity and a …
rescue of CFTR (cystic fibrosis [CF] transmembrane conductance regulator) activity and a …
Progression of lung disease in preschool patients with cystic fibrosis
Rationale: Implementation of intervention strategies to prevent lung damage in early cystic
fibrosis (CF) requires objective outcome measures that capture and track lung disease …
fibrosis (CF) requires objective outcome measures that capture and track lung disease …
Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial
Background Inhaled hypertonic saline enhances mucociliary clearance, improves lung
function, and reduces pulmonary exacerbations in people with cystic fibrosis older than age …
function, and reduces pulmonary exacerbations in people with cystic fibrosis older than age …
The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled …
HAWM Tiddens, Y Chen, ER Andrinopoulou… - The lancet Respiratory …, 2022 - thelancet.com
Summary Background In the Saline Hypertonic in Preschoolers (SHIP) study, inhaled 7%
hypertonic saline improved the lung clearance index in children aged 3–6 years with cystic …
hypertonic saline improved the lung clearance index in children aged 3–6 years with cystic …
Improvement in lung clearance index and chest computed tomography scores with elexacaftor/tezacaftor/ivacaftor treatment in people with cystic fibrosis aged 12 …
Rationale: Clinical trials have shown that use of elexacaftor/tezacaftor/ivacaftor (ETI) is
associated with improvements in sweat chloride, pulmonary function, nutrition, and quality of …
associated with improvements in sweat chloride, pulmonary function, nutrition, and quality of …
Global Lung Function Initiative reference values for multiple breath washout indices
KA Ramsey, S Stanojevic, L Chavez… - European …, 2024 - publications.ersnet.org
Background Multiple breath washout is a lung function test based on tidal breathing that
assesses lung volume and ventilation distribution. The aim of this analysis was to use the …
assesses lung volume and ventilation distribution. The aim of this analysis was to use the …
[引用][C] Normative data for multiple breath washout outcomes in school-aged Caucasian children
P Anagnostopoulou, P Latzin, R Jensen… - European …, 2020 - Eur Respiratory Soc