Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in
AD pathogenesis. More recent advances in understanding of the human genome …

We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a
subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush …

We used a collection of 708 prospectively collected autopsied brains to assess the
methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that …

Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …

Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

The dominant hypothesis of Alzheimer's disease (AD) aetiology, the neuropathological
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …

Alzheimer's disease (AD) and related dementias are a major public health challenge and
present a therapeutic imperative for which we need additional insight into molecular …

Genome-wide association studies (GWAS) originally identified ATP-binding cassette, sub-
family A, member 7 (ABCA7), as a novel risk gene of Alzheimer's disease (AD). Since then …

To date, the development of disease-modifying therapies for Alzheimer's disease (AD) has
largely focused on the removal of amyloid beta Aβ fragments from the CNS. Proteomic …