The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …

Pathogenesis by mycobacteria requires the exploitation of host-cell signalling pathways to
enhance the intracellular survival and persistence of the pathogen. The disruption of these …

The Mycobacterium tuberculosis genome contains 11 serine/threonine kinase genes
including two, pknA and pknB, that are part of an operon encoding genes involved in cell …

Though an essential trace element, manganese is generally accorded little importance in
biology other than as a cofactor for some free radical detoxifying enzymes and in the …

A family of eukaryotic-like Ser/Thr protein kinases occurs in bacteria, but little is known about
the structures and functions of these proteins. Here we characterize PknB, a transmembrane …

Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is one of the most
successful pathogens in human history. An extremely resilient cell wall and highly evolved …

Resuscitation-promoting factor (Rpf) is a muralytic enzyme that increases the culturability of
dormant bacteria. Recently, considerable progress has been made in understanding the …

Bacteria possess a repertoire of versatile protein kinases modulating diverse aspects of their
physiology by phosphorylating proteins on various amino acids including histidine, cysteine …

Reversible protein phosphorylation is a major regulation mechanism of fundamental
biological processes, not only in eukaryotes but also in bacteria. A growing body of evidence …

With the advent of the sequencing programs of prokaryotic genomes, many examples of the
presence of serine/threonine protein kinases in these organisms have been identified …