Crystal structure of a prokaryotic homologue of the mammalian oligopeptide–proton symporters, PepT1 and PepT2

S Newstead, D Drew, AD Cameron, VLG Postis… - The EMBO …, 2011 - embopress.org
PepT1 and PepT2 are major facilitator superfamily (MFS) transporters that utilize a proton
gradient to drive the uptake of di‐and tri‐peptides in the small intestine and kidney …

Dipeptidyl‐peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis

TK Nemoto, Y Ohara Nemoto - Molecular oral microbiology, 2021 - Wiley Online Library
Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic
microorganism that solely utilizes nutritional amino acids as its energy source and cellular …

[HTML][HTML] Oligopeptide signaling through TbGPR89 drives trypanosome quorum sensing

F Rojas, E Silvester, J Young, R Milne, M Tettey… - Cell, 2019 - cell.com
Trypanosome parasites control their virulence and spread by using quorum sensing (QS) to
generate transmissible" stumpy forms" in their host bloodstream. However, the QS signal" …

Alternating access mechanism in the POT family of oligopeptide transporters

N Solcan, J Kwok, PW Fowler, AD Cameron… - The EMBO …, 2012 - embopress.org
Short chain peptides are actively transported across membranes as an efficient route for
dietary protein absorption and for maintaining cellular homeostasis. In mammals, peptide …

[HTML][HTML] Multispecific substrate recognition in a proton-dependent oligopeptide transporter

MM Molledo, EM Quistgaard, A Flayhan, J Pieprzyk… - Structure, 2018 - cell.com
Proton-dependent oligopeptide transporters (POTs) are important for uptake of dietary di-
and tripeptides in many organisms, and in humans are also involved in drug absorption …

[HTML][HTML] Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

V Kotov, M Killer, KEJ Jungnickel, J Lei, G Finocchio… - Cell Reports, 2023 - cell.com
Proton-dependent oligopeptide transporters (POTs) are promiscuous transporters of the
major facilitator superfamily that constitute the main route of entry for a wide range of dietary …

Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family

S Newstead - Biochemical Society Transactions, 2011 - portlandpress.com
One of the principal aims of modern drug design is the targeted delivery of drugs within the
body, such as to the central nervous system, combined with their exclusion from the liver and …

[HTML][HTML] Crystal structure of the E. coli peptide transporter YbgH

Y Zhao, G Mao, M Liu, L Zhang, X Wang, XC Zhang - Structure, 2014 - cell.com
E. coli YbgH belongs to the family of proton-dependent oligopeptide transporters (POTs), a
subfamily of the major facilitator superfamily (MFS) of secondary active transporters. Like …

[HTML][HTML] Structural basis of malodour precursor transport in the human axilla

GS Minhas, D Bawdon, R Herman, M Rudden… - Elife, 2018 - elifesciences.org
Mammals produce volatile odours that convey different types of societal information. In
Homo sapiens, this is now recognised as body odour, a key chemical component of which is …

Elucidating acetate tolerance in E. coli using a genome-wide approach

NR Sandoval, TY Mills, M Zhang, RT Gill - Metabolic engineering, 2011 - Elsevier
Engineering organisms for improved performance using lignocellulose feedstocks is an
important step towards a sustainable fuel and chemical industry. Cellulosic feedstocks …