Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible
for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil …

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family,
binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express …

APO‐1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces
apoptosis upon receptor oligomerization. In a search to identify intracellular signaling …

Abstract Fas/APO-1 and p55 tumor necrosis factor (TNF) receptor (p55-R) activate cellular
mechanisms that result in cell death. Upon activation of these receptors, Fas/APO-1 binds a …

Abstract CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of
an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the …

Ligation of the extracellular domain of the cell surface receptor Fas/APO-1 (CD95) elicits a
characteristic programmed death response in susceptible cells. Using a genetic selection …

▪ Abstract Apoptosis of mature T lymphocytes preserves peripheral homeostasis and
tolerance by countering the profound changes in the number and types of T cells stimulated …

In 1989 we published a paper describing the discovery of an apoptosis-inducing receptor
[1]. We named this receptor APO-1, anticipating that it might be the first of a series of …

A fundamental property of animal cells is the ability to regulate their own cell volume. Even
under hypotonic stress imposed by either decreased extracellular or increased intracellular …

▪ Abstract Regulation of the homeostatic balance between cell proliferation and cell death is
essential for development and maintenance of multicellular organisms. Physiologic, or …