Chemotherapy-induced cognitive impairment and hippocampal neurogenesis: a review of physiological mechanisms and interventions
MJ Sekeres, M Bradley-Garcia… - International journal of …, 2021 - mdpi.com
A wide range of cognitive deficits, including memory loss associated with hippocampal
dysfunction, have been widely reported in cancer survivors who received chemotherapy …
dysfunction, have been widely reported in cancer survivors who received chemotherapy …
Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING …
Objectives Oxaliplatin induces chemobrain in cancer patients/survivors. Nutraceutical
naringin has antioxidant and anti-inflammatory properties with low oral bioavailability. Our …
naringin has antioxidant and anti-inflammatory properties with low oral bioavailability. Our …
[HTML][HTML] Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment
Z Yao, H Dong, J Zhu, L Du, Y Luo, Q Liu, S Liu, Y Lin… - JCI insight, 2023 - ncbi.nlm.nih.gov
Chemotherapy-related cognitive impairment (CRCI) or “chemo brain” is a devastating
neurotoxic sequela of cancer-related treatments, especially for the elderly individuals. Here …
neurotoxic sequela of cancer-related treatments, especially for the elderly individuals. Here …
Implication of M2 macrophage on NLRP3 inflammasome signaling in mediating the neuroprotective effect of Canagliflozin against methotrexate-induced cognitive …
LH Khedr, RM Rahmo, OM Eldemerdash… - International …, 2024 - Elsevier
Methotrexate (MTX), a chemotherapeutic antimetabolite, has been linked to cognitive
impairment in cancer patients. MTX-induced metabolic pathway disruption may result in …
impairment in cancer patients. MTX-induced metabolic pathway disruption may result in …
Methodological shortcomings of preclinical research on chemotherapy-induced cognitive impairment
VA Ossorio-Salazar, R D'Hooge - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
In Europe, an estimated 4 million new cancer cases were diagnosed in 2020 (ECIS-
European Cancer Information System, 2023). Patients' chances of survival improved …
European Cancer Information System, 2023). Patients' chances of survival improved …
[HTML][HTML] Artificial and natural interventions for chemotherapy-and/or radiotherapy-induced cognitive impairment: A systematic review of animal studies
LE Kuil, T Varkevisser, MH Huisman, M Jansen… - Neuroscience & …, 2024 - Elsevier
Background Cancer survivors frequently experience cognitive impairments. This systematic
review assessed animal literature to identify artificial (pharmaceutical) or natural …
review assessed animal literature to identify artificial (pharmaceutical) or natural …
Early life cancer and chemotherapy lead to cognitive deficits related to alterations in microglial-associated gene expression in prefrontal cortex
CJ Laaker, C Cantelon, AB Davis, KR Lloyd… - Brain, Behavior, and …, 2023 - Elsevier
Children that survive leukemia are at an increased risk for cognitive difficulties. A better
understanding of the neurobiological changes in response to early life chemotherapy will …
understanding of the neurobiological changes in response to early life chemotherapy will …
[HTML][HTML] The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype
T Demby, PS Gross, J Mandelblatt, JK Huang… - Experimental …, 2024 - Elsevier
Many cancer patients experience serious cognitive problems related to their treatment,
which can greatly affect their quality of life. The molecular mechanisms of this cancer …
which can greatly affect their quality of life. The molecular mechanisms of this cancer …
Chemotherapy-Mediated Neuronal Aberration
PK Jaiswara, SK Shukla - Pharmaceuticals, 2023 - mdpi.com
Chemotherapy is a life-sustaining therapeutic option for cancer patients. Despite the
advancement of several modern therapies, such as immunotherapy, gene therapy, etc …
advancement of several modern therapies, such as immunotherapy, gene therapy, etc …
Wnt3a/GSK3β/β-catenin Signalling Modulates Doxorubicin-associated Memory Deficits in Breast Cancer
W Li, C Gan, S Yu, J Xu, LX Tang, H Cheng - Molecular Neurobiology, 2024 - Springer
Background: Chemobrain is widespread in breast cancer patients receiving chemotherapy.
However, the exact mechanism, especially the associated signalling pathway, is not …
However, the exact mechanism, especially the associated signalling pathway, is not …