ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of
the most successfully adapted human pathogens. Human-to-human transmission occurs at …
the most successfully adapted human pathogens. Human-to-human transmission occurs at …
[HTML][HTML] Genome wide approaches discover novel Mycobacterium tuberculosis antigens as correlates of infection, disease, immunity and targets for vaccination
M Coppola, THM Ottenhoff - Seminars in immunology, 2018 - Elsevier
Every day approximately six thousand people die of Tuberculosis (TB). Its causative agent,
Mycobacterium tuberculosis (Mtb), is an ancient pathogen that through its evolution …
Mycobacterium tuberculosis (Mtb), is an ancient pathogen that through its evolution …
A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin
JS Woodworth, HS Clemmensen, H Battey… - Nature …, 2021 - nature.com
Given the encouraging clinical results of both candidate subunit vaccines and revaccination
with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for …
with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for …
Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial
Background Infants are a key target population for new tuberculosis vaccines. We assessed
the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine …
the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine …
Dose optimization of H56: IC31 vaccine for tuberculosis-endemic populations. A double-blind, placebo-controlled, dose-selection trial
S Suliman, AKK Luabeya, H Geldenhuys… - American journal of …, 2019 - atsjournals.org
Rationale: Global tuberculosis (TB) control requires effective vaccines in TB-endemic
countries, where most adults are infected with Mycobacterium tuberculosis (M. tb) …
countries, where most adults are infected with Mycobacterium tuberculosis (M. tb) …
A phase 1b randomized study of the safety and immunological responses to vaccination with H4: IC31, H56: IC31, and BCG revaccination in Mycobacterium …
LG Bekker, O Dintwe, A Fiore-Gartland… - …, 2020 - thelancet.com
Background Tuberculosis (TB) remains the leading cause of infectious disease-related
death. Recently, a trial of BCG revaccination and vaccination with H4: IC31, a recombinant …
death. Recently, a trial of BCG revaccination and vaccination with H4: IC31, a recombinant …
Clinical utility of existing and second-generation interferon-γ release assays for diagnostic evaluation of tuberculosis: an observational cohort study
HS Whitworth, A Badhan, AA Boakye… - The Lancet Infectious …, 2019 - thelancet.com
Background The clinical utility of interferon-γ release assays (IGRAs) for diagnosis of active
tuberculosis is unclear, although they are commonly used in countries with a low incidence …
tuberculosis is unclear, although they are commonly used in countries with a low incidence …
Mycobacterium tuberculosis-Specific T Cell Functional, Memory, and Activation Profiles in QuantiFERON-Reverters Are Consistent With Controlled Infection
CAM Mpande, P Steigler, T Lloyd, V Rozot… - Frontiers in …, 2021 - frontiersin.org
Reversion of immune sensitization tests for Mycobacterium tuberculosis (M. tb) infection,
such as interferon-gamma release assays or tuberculin skin test, has been reported in …
such as interferon-gamma release assays or tuberculin skin test, has been reported in …
Use of T cell mediated immune functional assays for adjustment of immunosuppressive or anti-infective agents in solid organ transplant recipients: a systematic review
O Rezahosseini, DL Møller, AD Knudsen… - Frontiers in …, 2020 - frontiersin.org
Background: Defining the optimal dosage of the immunosuppressive or duration of anti-
infective agents is a challenge in solid organ transplant (SOT) recipients. We aimed to …
infective agents is a challenge in solid organ transplant (SOT) recipients. We aimed to …
Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection
S Panda, J Morgan, C Cheng, M Saito… - Nature …, 2024 - nature.com
There is still incomplete knowledge of which Mycobacterium tuberculosis (Mtb) antigens can
trigger distinct T cell responses at different stages of infection. Here, a proteome-wide screen …
trigger distinct T cell responses at different stages of infection. Here, a proteome-wide screen …