Concealed Substrates in Brugada Syndrome: Isolated Channelopathy or Associated Cardiomyopathy?

C Di Resta, J Berg, A Villatore, M Maia, G Pili… - Genes, 2022 - mdpi.com
Simple summary Having a new and more precise definition of BrS, based on its
cardiomyopathic component, may be crucial to meliorate the current clinical management of …

Electrophysiological patterns and structural substrates of Brugada syndrome: Critical appraisal and computational analyses

P Seghetti, S Latrofa, N Biasi… - Journal of …, 2024 - Wiley Online Library
Brugada syndrome (BrS) is a cardiac electrophysiological disease with unknown etiology,
associated with sudden cardiac death. Symptomatic patients are treated with implanted …

High-risk Brugada syndrome: factors associated with arrhythmia recurrence and benefits of epicardial ablation in addition to implantable cardioverter defibrillator …

V Santinelli, G Ciconte, F Manguso, L Anastasia… - Europace, 2024 - academic.oup.com
Aims This study aims to evaluate the prognostic impact of the arrhythmogenic substrate size
in symptomatic Brugada syndrome (BrS) as well as to validate the long-term safety and …

[HTML][HTML] Longitudinal assessment of structural phenotype in Brugada syndrome using cardiac magnetic resonance imaging

JC Isbister, B Gray, S Offen, L Yeates, C Naoum… - Heart Rhythm O2, 2023 - Elsevier
Background Despite historically being considered a channelopathy, subtle structural
changes have been reported in Brugada syndrome (BrS) on histopathology and cardiac …

The many faces of SCN5A pathogenic variants: from channelopathy to cardiomyopathy

I Vouloagkas, A Agbariah, T Zegkos, TD Gossios… - Heart Failure …, 2024 - Springer
The SCN5A gene encodes the alpha subunit of the cardiac sodium channel, which plays a
fundamental role in the generation and propagation of the action potential in the heart …

The “arrhythmic” presentation of peripartum cardiomyopathy: case series and critical review of the literature

G Peretto, E Micaglio, G Ciconte, M Maia… - Frontiers in …, 2024 - frontiersin.org
Peripartum Cardiomyopathy (PPCM) is a polymorphic myocardial disease occurring late
during pregnancy or early after delivery. While reduced systolic function and heart failure …

Delayed depolarization and histologic abnormalities underlie the Brugada syndrome

B Martini, N Martini, L De Mattia… - Pacing and Clinical …, 2023 - Wiley Online Library
Brugada syndrome (BrS) is a controversial disease whose pathophysiology is still far from
being fully understood. Unlike other cardiological disorders, a definite etiology has not yet …

Electrocardiographic temporo-spatial assessment of depolarization and repolarization changes after epicardial arrhythmogenic substrate ablation in Brugada …

ET Locati, PM Van Dam, G Ciconte… - … Heart Journal-Digital …, 2023 - academic.oup.com
Abstract Aims In Brugada syndrome (BrS), with spontaneous or ajmaline-induced coved ST
elevation, epicardial electro-anatomic potential duration maps (epi-PDMs) were detected on …

Late gadolinium enhancement in early repolarization syndrome

H Morita, S Asada, S Nagase, A Ueoka, T Masuda… - Heart Rhythm, 2024 - Elsevier
Abstract Background In patients with Brugada syndrome, myocardial fibrosis can be
identified through epicardial biopsy or cardiac magnetic resonance (CMR) imaging with late …

Predicting ventricular arrhythmia inducibility in ajmaline‐induced Brugada type I pattern: Validation of the dST‐Tiso interval

S Iacopino, E Fabiano, P Sorrenti… - Journal of …, 2024 - Wiley Online Library
Abstract Introduction The dST‐Tiso is a newly proposed electrocardiographic (ECG) marker
during Brugada (BrS) type I pattern, that predicts the likelihood of ventricular arrhythmia (VA) …