[HTML][HTML] Networks beyond pairwise interactions: Structure and dynamics
The complexity of many biological, social and technological systems stems from the richness
of the interactions among their units. Over the past decades, a variety of complex systems …
of the interactions among their units. Over the past decades, a variety of complex systems …
Progress and promise of genome-wide association studies for human complex trait genetics
Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These …
There has been early success for prevalent diseases with complex phenotypes. These …
Secretory protein biogenesis and traffic in the early secretory pathway
CK Barlowe, EA Miller - Genetics, 2013 - academic.oup.com
The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse
array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum …
array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum …
Membrane protein insertion at the endoplasmic reticulum
S Shao, RS Hegde - Annual review of cell and developmental …, 2011 - annualreviews.org
Integral membrane proteins of the cell surface and most intracellular compartments of
eukaryotic cells are assembled at the endoplasmic reticulum. Two highly conserved and …
eukaryotic cells are assembled at the endoplasmic reticulum. Two highly conserved and …
Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels
Recent progress in neuroscience has been facilitated by tools for neuronal activation and
inactivation that are orthogonal to endogenous signaling systems. We describe here a …
inactivation that are orthogonal to endogenous signaling systems. We describe here a …
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as
mRNA processing. Although highly conserved throughout all organisms, their biological …
mRNA processing. Although highly conserved throughout all organisms, their biological …
The genetic basis of music ability
Music is an integral part of the cultural heritage of all known human societies, with the
capacity for music perception and production present in most people. Researchers generally …
capacity for music perception and production present in most people. Researchers generally …
Mapping of signaling networks through synthetic genetic interaction analysis by RNAi
The analysis of synthetic genetic interaction networks can reveal how biological systems
achieve a high level of complexity with a limited repertoire of components. Studies in yeast …
achieve a high level of complexity with a limited repertoire of components. Studies in yeast …
The cancer cell map initiative: defining the hallmark networks of cancer
Progress in DNA sequencing has revealed the startling complexity of cancer genomes,
which typically carry thousands of somatic mutations. However, it remains unclear which are …
which typically carry thousands of somatic mutations. However, it remains unclear which are …
[HTML][HTML] Post-translational translocation into the endoplasmic reticulum
N Johnson, K Powis, S High - … et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
Proteins destined for the endomembrane system of eukaryotic cells are typically
translocated into or across the membrane of the endoplasmic reticulum and this process is …
translocated into or across the membrane of the endoplasmic reticulum and this process is …