There is increasing interest among functional neurosurgeons in the potential for novel
therapies to impact upon diseases beyond movement disorders and pain. A target of …

Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic
regions of brain thought to be responsible for long-term behavioral plasticity driving …

Despite the importance of numerous psychosocial factors, at its core, drug addiction involves
a biological process: the ability of repeated exposure to a drug of abuse to induce changes …

In contrast with the many studies of stress effects on the brain, relatively little is known about
the molecular mechanisms of resilience, the ability of some individuals to escape the …

Drug-evoked synaptic plasticity is observed at many synapses and may underlie
behavioural adaptations in addiction. Mechanistic investigations start with the identification …

Rationale Love has long been referred to as an addiction in literature and poetry. Scientists
have often made comparisons between social attachment processes and drug addiction …

Nicotine abuse and addiction is a major health liability. Nicotine, an active alkaloid in
tobacco, is self-administered by animals and produces cellular adaptations in brain regions …

Cortico-striatal glutamate transmission has been implicated in both the initiation and
expression of addiction related behaviors, such as locomotor sensitization and drug …

Addictive drugs hijack mechanisms of learning and memory that normally underlie
reinforcement of natural rewards and induce synaptic plasticity of glutamatergic transmission …