RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

ETS-domain transcription-factor networks represent a model for how combinatorial gene
expression is achieved. These transcription factors interact with a multitude of co-regulatory …

Transcription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few
mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which …

Childhood leukaemia is the principal subtype of paediatric cancer and, despite success in
treatment, its causes remain enigmatic. A plethora of candidate environmental exposures …

Background Hereditary predisposition is rarely suspected for childhood acute lymphoblastic
leukaemia (ALL). Recent reports of germline ETV6 variations associated with substantial …

The RUNX genes have come to prominence recently because of their roles as essential
regulators of cell fate in development and their paradoxical effects in cancer, in which they …

Histone deacetylase 3 (Hdac3) is an enzymatic component of transcriptional repression
complexes recruited by the nuclear hormone receptors. Inactivation of Hdac3 in cancer cell …

Translocations involving band 12p13 are one of the most commonly observed chromosomal
abnormalities in human leukemia and myelodysplastic syndrome. Their frequently result in …

TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a
large number of hematalogical malignancies. These rearrangements fuse a potent …

Innate immune responses to bacterial or viral infection require rapid transition of large
cohorts of inflammatory response genes from poised/repressed to actively transcribed …