Phytobioactive compounds as therapeutic agents for human diseases: A review

M Riaz, R Khalid, M Afzal, F Anjum… - Food Science & …, 2023 - Wiley Online Library
Phytobioactive compounds are plant secondary metabolites and bioactive compounds
abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative …

Synthesis and biological activity of 1, 3, 4-oxadiazoles used in medicine and agriculture

M Luczynski, A Kudelko - Applied Sciences, 2022 - mdpi.com
Biologically active compounds play a key role in the fight against diseases affecting both
human and animal living organisms, as well as plants. Finding out about new molecules …

New indole based hybrid oxadiazole scaffolds with N-substituted acetamides: As potent anti-diabetic agents

M Nazir, MA Abbasi, SZ Siddiqui, KM Khan, U Salar… - Bioorganic …, 2018 - Elsevier
Current study is based on the sequential conversion of indolyl butanoic acid (1) into ethyl
indolyl butanoate (2), indolyl butanohydrazide (3), and 1, 3, 4-oxadiazole-2-thiol analogs (4) …

Synthesis of novel Azol-β-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their …

A Mermer, H Bayrak, Y Şirin, M Emirik… - Journal of Molecular …, 2019 - Elsevier
This study reports the synthesis, biological investigation and molecular docking of novel β-
lactam derivatives bearing 1, 3, 4-thiadiazole and 1, 3, 4-oxadiazole ring system. The …

Novel indole based hybrid oxadiazole scaffolds with N-(substituted-phenyl) butanamides: synthesis, lineweaver–burk plot evaluation and binding analysis of potent …

M Nazir, MA Abbasi, SZ Siddiqui, H Raza, M Hassan… - RSC …, 2018 - pubs.rsc.org
In the study presented herein, 4-(1H-indol-3-yl) butanoic acid (1) was sequentially
transformed in the first phase into ethyl 4-(1H-indol-3-yl) butanoate (2), 4-(1H-indol-3-yl) …

One-Pot CuO-Catalyzed Green Synthesis of N(N′)-Arylbenzamidines as Potential Enzyme Inhibitors

MB Taj, A Raheel, W Alelwani, N Babteen… - Russian Journal of …, 2019 - Springer
Abstract Ten N (N′)-arylbenzamidines were synthesized in 60–77% yield by one-pot
microwave-assisted reaction of the corresponding N-arylbenzamides with aniline or …

Synthesis, characterization, anti-mycobacterial activity and in silico study of new 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives

MNAM Taib, NS Hasmaruddin, NAM Ali, H Osman… - 2022 - researchsquare.com
Abstract A series of new 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives (5a-j and 6a-j) have
been designed and synthesized in four-steps. sixteen compounds among the twenty …

[PDF][PDF] Anti-inflammatory, antithrombotic and molecular docking studies of 1, 3, 4 Oxadiazole derivatives in rats

MAR Basra, M Batool, F Farhat, A Tajammal… - J Biomedical …, 2019 - academia.edu
Abstract Background: 1, 3, 4-Oxadiazole have been reported for the diverse use in medicine
because of its versatile pharmacological properties. In continuation of our on-going research …

[PDF][PDF] Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl) propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with …

AA Shah, M Shahid, H Fatima, S Iftikhar… - Pakistan Journal of …, 2019 - researchgate.net
In the study presented here, the nucleophilic substitution reaction of 5-[3-(1H-indol-3-yl)
propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide was carried out with different alkyl/aralkyl halides …

Synthesis, Characterization, and Anti-Mycobacterial Activity of New 5-Substituted-1, 3, 4-Oxadiazole-2-Thiols

MNA Mohamad Taib, NS Hasmaruddin… - Zaheen and Abd Ghani … - papers.ssrn.com
A series of new 2-alkylbenzysulfanyl-5-substituted-1, 3, 4-oxadiazoles derivatives (5a-j and
6a-j) were synthesized in four-step reaction from carboxylic acid analogues as the starting …