Positional specification by morphogen gradients is traditionally viewed as a two-step
process. A gradient is formed and then interpreted, providing a spatial metric independent of …

The mammalian cochlea develops from a ventral outgrowth of the otic vesicle in response to
Shh signaling. Mouse embryos lacking Shh or its essential signal transduction components …

Sonic hedgehog (Shh) is well known as the molecule responsible for the induction and
maintenance of ventral neural tube structures. Recent data have shown that ventral …

The spatially restricted expression of cadherin‐7 to the intermediate domain of the neural
epithelium and in migrating neural crest cells during early neural development is potentially …

Proper movement of the vertebrate eye requires the formation of precisely patterned axonal
connections linking cranial somatic motoneurons, located at defined positions in the ventral …

Neural tube defects, one of the most common human birth defects worldwide, have a
multifactorial etiology and significant association with maternal folate status. Folate is …

The Developing Brain and Its Connections describes the processes of neural development
from neural induction through synaptic refinement. Each chapter explores specific …

The differentiation of stem cells into the more than 100 billion neurons that compose the
central nervous system (CNS) is one of the most remarkable transformations during …